Discover and read the best of Twitter Threads about #arthrits

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Back to basics‼️

A tweetorial on a clinical approach to #joint #pain 🪡
1/n

The 🔠ABCDE approach

🅰️ Articular (or not!) 🦴
🅱️ Background (& burden) 🎒
C Chronology 🕰️
D Distribution 📍
E Extra-articular 🍂

Let’s dive deeper

#MedTwitter
#RheumTwitter ImageImageImage
2/n
#Pain is #inflammatory if worst in the AM/ after rest

#Swelling which is not bony #Synovitis the sine qua non of #inflammatory #arthrits

#Stiffness esp in AM & > 1 hour

“How do you feel when you wake in the morning?”

is a great question to ask

#MedTwitter
#RheumTwitter ImageImageImageImage
3/n
🅱️ = BACKGROUND

Age 🕰️
Gender ♈️♎️
Race 🧕🏻
#Comorbidities
Pregnancy🤱🏻

And 🅱️ = Burden👩🏻‍🦼
#impact of disease

#MedTwitter
#RheumTwitter ImageImageImageImage
Read 6 tweets
#Methotrexate is the nr1⃣drug of choice for Rheumatoid #Arthritis.

MTX's history is eventful, and deserves a 🧵

🔹It started with childhood leukeamia
🔹Sleeping Beauty in the 1960-70's
🔹Awakened by Hoffmeister
🔹FDA👍1988 and 🔝 in the 1990's

1/🧵 #RheumTwitter #MedTwitter
The start:
🔹1948, Dr Farber treated 5 children with #leukemia with Aminopterin, an anti-folate & precursor of #MTX, with outstanding results

🔹1951, first positive results of Aminopterin in #RA & #Psoriasis pts

Despite this, Aminopterin was aborted in RA

2/🧵 #RheumTwitter
MTX enters:
Due to difficulties in manufacturing, Aminopterin was modified and MTX was created.

🔹1962, positive results with MTX in both RA and #PSA

🔹Next 10 years: MTX was extensively studied in #psoriasis but halted in #RA

🔹In RA, MTX becomes the Sleeping Beauty👸💤

3/🧵
Read 10 tweets

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