Discover and read the best of Twitter Threads about #asco2020
Most recents (3)
Here's what seems clear from the #ASCO2020 abstracts on tumor-normal (#germline) sequencing of #cancer patients:
(1) A significant minority of cancer patients (5-15%) harbor clinically-actionable variants, such as those indicating PARP inhibition or immunotherapy use.
(1) A significant minority of cancer patients (5-15%) harbor clinically-actionable variants, such as those indicating PARP inhibition or immunotherapy use.
(2) More patients will benefit if we broaden gene panels. However, it's vital to control for incidental findings and variants of unknown significance (VUSs). This may require highly scalable, space-age variant interpretation that lives on the frontier of clinical research.
(3) Point-of-core tumor-normal testing isn't going to cut it. There are challenges with turnaround time, scalability, clinician education, discordant variant interpretation, and high cost. Germline guesswork from tumor tissue is shaky and likely not the solution to this issue. 
For those of you who come across the few CPX-351 (Vyxeos) #ASCO2020 abstracts still trying to spin that data positively 🙄, let me save you some time - See our 3 part #tweetorial on why you shouldn’t use this drug 🚮:
#oncstewardship
cc: @AnthonyPerissi2 @Lydialbc
#oncstewardship
cc: @AnthonyPerissi2 @Lydialbc
Part 1️⃣ - sAML background
Part 2️⃣ - CPX-351 - flaws and comparisons
The new year begins and I usher into a scientific journey where I shall be challenging myself with scientific quest and reviewing a scientific article/blog/interview/technique or facts on a daily basis. (or at least try😉) #365DaysOfScience
Let the journey begin.
Let the journey begin.
The most cited article (over 300,000 times) is the @jbiolchem paper for a technique to estimate protein concentration in a solution. The paper is "Protein measurement with the folin phenol reagent".
#365DaysOfScience
Image: @nature
#365DaysOfScience
Image: @nature
Yes, the classic Lowry's method was published in May 1951. This is a colourimetric assay which gives an estimation of the amount of protein based on a standard curve obtained from a protein of known concentration (usually BSA).
#365DaysOfScience
#365DaysOfScience
