Discover and read the best of Twitter Threads about #ash23

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1/ My time-to-tweet interval re: #ASCO23 myeloma abstracts is longer than my time-to-toci with CAR-T, but finally off 🏥 service and excited to tweet about a few #MMsm gems!

My research focuses on ⬇️ AEs, ⬇️ time tox, & improved workflows. Here are a few that stood out to me:
2/ @bhemato et al, CARTITUDE-4 (cilta-cel in #MMsm 1-3 prior lines).

Beyond dramatic PFS benefit, worth 🔨 home that CAR-T "one & done" (visits become ≤1x per month) vs DPd/VPd [even stronger DKd] always ≥1x visit/month.

Time tox advantage to CAR-T!

meetings.asco.org/abstracts-pres… Image
3/ @adamssperling et al, PHE885 rapidly manufactured CAR-T with ⬇️ T-cell exhaustion.

Bridging before #MMsm CAR-T unlikely to ≥PR but likely to worsen cytopenias.

⬇️ vein-to-vein time to ~2 weeks: less bridging, happier bone marrow, happier patients!

meetings.asco.org/abstracts-pres… Image
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