Discover and read the best of Twitter Threads about #aspirin
Most recents (19)
1/
Second day of @Smart_Meeting_M
Professor @giovannilandoni talking about management of #anticoagulant in #perioperative patients 💉
✅You surely all know how to deal with #antithrombotic and #regionalanesthesia, here the guidelines:
pubmed.ncbi.nlm.nih.gov/34980845/
#FOAMed #FOAMcc
Second day of @Smart_Meeting_M
Professor @giovannilandoni talking about management of #anticoagulant in #perioperative patients 💉
✅You surely all know how to deal with #antithrombotic and #regionalanesthesia, here the guidelines:
pubmed.ncbi.nlm.nih.gov/34980845/
#FOAMed #FOAMcc
2/
💡Let's focus on perioperative #DOAC /#NOAC / #TSOAC
➡️Consider both #surgical blood loss risk and #patient characteristics.
⚠️Remember NOT to bridge with #LMWH or #UFH.
pubmed.ncbi.nlm.nih.gov/33895845/
💡Let's focus on perioperative #DOAC /#NOAC / #TSOAC
➡️Consider both #surgical blood loss risk and #patient characteristics.
⚠️Remember NOT to bridge with #LMWH or #UFH.
pubmed.ncbi.nlm.nih.gov/33895845/
3/
What if it's not an elective patient??
Use #reversal agents when needed❗
🔹#Idarucizumab for #dabigatran
🔹#Andexanet for #apixaban and #rivaroxaban
💡#Prothrombin complex concentrates in addiction
pubmed.ncbi.nlm.nih.gov/36988142/
What if it's not an elective patient??
Use #reversal agents when needed❗
🔹#Idarucizumab for #dabigatran
🔹#Andexanet for #apixaban and #rivaroxaban
💡#Prothrombin complex concentrates in addiction
pubmed.ncbi.nlm.nih.gov/36988142/
The risk of bleeding with #aspirin outweighs its benefits in people without Atherosclerotic Cardiovascular Disease (ASCVD)
1. Aspirin is sometimes recommended to prevent #heartattack and stroke in people without ASCVD. A recent research looked at its benefits versus risks.
1. Aspirin is sometimes recommended to prevent #heartattack and stroke in people without ASCVD. A recent research looked at its benefits versus risks.
2. Aspirin reduced the risk of heart attack by 15% but increased the risk of major bleeding by 48%, making effects of aspirin overall negative.
Aspirin did not reduce the risk of death.
#MedTwitter #CardioTwitter
doi.org/10.1016/j.jaca…
Aspirin did not reduce the risk of death.
#MedTwitter #CardioTwitter
doi.org/10.1016/j.jaca…
3. In the study group, statin use reduced the risk of heart attack without increasing bleeding risk.
1/🚨New Episode🚨
Aspirin for Primary Prevention: #MindtheGap Segment
What do current ACC and USPSTF guidelines say about daily low-dose #aspirin for the primary prevention of #cardiovascular disease?
🎧: apple.co/3VPRCV4
Sponsor: bit.ly/TCChoZ
Aspirin for Primary Prevention: #MindtheGap Segment
What do current ACC and USPSTF guidelines say about daily low-dose #aspirin for the primary prevention of #cardiovascular disease?
🎧: apple.co/3VPRCV4
Sponsor: bit.ly/TCChoZ
2/Throwback to medical school pathophysiology!
Remember how the #atherosclerotic process takes place in blood vessels? 🫀
Now, where does #aspirin exert its effect during this cascade? 🤔
Remember how the #atherosclerotic process takes place in blood vessels? 🫀
Now, where does #aspirin exert its effect during this cascade? 🤔
3/What do the most recent #RCTs inform us about the use of aspirin for primary prevention ⁉️
ASCEND, ARRIVE, ASPREE!
#CoreIMJournalClub 📕
ASCEND, ARRIVE, ASPREE!
#CoreIMJournalClub 📕
1) Welcome to an #accredited #tweetorial on a unique emerging (in Ph3 now) option for specifically reversing the #antiplatelet effects of #ticagrelor: it's #bentracimab. Expert faculty is antithrombotic agent reversal guru @md_pollack of @UMMCnews, working to create #AHealthierMS
2) This program is intended for #healthcare professionals and is supported by an educational grant from PhaseBio Pharmaceuticals. Faculty disclosures are listed at cardiometabolic-ce.com/disclosures/, and prior programs are available for 🆓CE/#CME credit at cardiometabolic-ce.com.
3) It is an unfortunate fact of life that one cannot prescribe #anticoagulant or #antiplatelet (together, #antithrombotic) therapy without increasing a patient's #bleedingrisk. That is why it should be an individualized risk:benefit decision, ideally . . .
Don’t miss a new accredited #tweetorial launching TOMORROW here on @cardiomet_CE. #Interventional #cardiologist, #researcher, & #SoMe education leader @DLBHATTMD will be talking all about #aspirin, its role in #cardiovascular wellness & prevention, and new approaches to . . .
. . . formulation and dosing. Don't miss it--FOLLOW US NOW! @cpcannon @AnnMarieNavar @DrM_ODonoghue @DrMarthaGulati @practicalcardio @GuyattGH @DrMauricioCohen @SVRaoMD @ASPCardio @PlateletDoc @stephanamayer @CMichaelGibson @JJheart_doc @DrSheilaSahni @mmamas1973 @Drroxmehran
1) Welcome to an #accredited #tweetorial on the foundational role of #aspirin in #cardiovascular care. There are new approaches to #aspirin formulation & dosing. This program is accredited for 0.50h CE/#CME. I am @DLBHATTMD. #FOAMed #cardiotwitter #medtwitter
Don’t miss a new accredited #tweetorial launching TOMORROW here on @cardiomet_CE. #Cardiologist, #SoMe education advocate, and true #Renaissance man @CMichaelGibson will be discussing a novel #aspirin prep that has PK/PD like plain #ASA . . .
. . . but a different site of absorption--with greater predictability than ECASA. DON'T MISS IT!! @DLBHATTMD @cpcannon @AnnMarieNavar @DrM_ODonoghue @DrMarthaGulati @practicalcardio @GuyattGH @DrMauricioCohen @SVRaoMD @ASPCardio @PlateletDoc @stephanamayer #FOAMed #CardioTwitter
1) Welcome to a #tweetorial where we’ll explore how changing the formulation of #aspirin & where it's absorbed in the GI tract can ⬇️the risk of acute GI injury, but still maintain predictable absorption. This program is accredited for 0.50h CE/#CME. I am @CMichaelGibson. #FOAMed
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
10 common causes of heavy menstrual flow you should know
1. Fibroids
2. Pelvic infections
3. Some drugs
4. Polyps
5. IUCDs
6. Endometriosis
7. Adenomyosis
8. Blood clotting problems
9. Cancers of the womb or cervix
10. Thyroid disease
A thread 🧵
{Share to who needs this!}
1. Fibroids
2. Pelvic infections
3. Some drugs
4. Polyps
5. IUCDs
6. Endometriosis
7. Adenomyosis
8. Blood clotting problems
9. Cancers of the womb or cervix
10. Thyroid disease
A thread 🧵
{Share to who needs this!}
If a woman loses more than 80ml of blood in one period, the bleeding is heavy. Heavy periods usually often come with blood clots.
Although methods of quantifying the exact amount of blood loss are not usually accurate, most women know when their period is heavy.
Although methods of quantifying the exact amount of blood loss are not usually accurate, most women know when their period is heavy.
Nearly 20% of women over 30 years have #fibroids.They are of different types & may cause heavy menstrual bleeding.
Treatment of fibroids depends on the many factors so see your doctor.
Treatment of fibroids depends on the many factors so see your doctor.
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
#ACC21 late-breakers🧵
1/Antiplatelets: Let's start with #aspirin
❌ADAPTABLE :Aspirin 325 mg vs 81 mg in ASCVD pts
No difference in death/ MI/ stroke/major bleeding
💎pragmatic trial: EHR-identified pts
💎significant dose switching in 325 mg group
nejm.org/doi/full/10.10…
1/Antiplatelets: Let's start with #aspirin
❌ADAPTABLE :Aspirin 325 mg vs 81 mg in ASCVD pts
No difference in death/ MI/ stroke/major bleeding
💎pragmatic trial: EHR-identified pts
💎significant dose switching in 325 mg group
nejm.org/doi/full/10.10…
✅Host Exam: Aspirin vs Clopidogrel in chronic Maintenance monotherapy after #PCI w/ DES
#Clopidogrel monotherapy reduced composite of death, non-fatal MI, stroke, ACS re-admission, BARC >=3 bleeding, compared to #aspirin monotherapy.
❓East Asian paradox
thelancet.com/journals/lance…
#Clopidogrel monotherapy reduced composite of death, non-fatal MI, stroke, ACS re-admission, BARC >=3 bleeding, compared to #aspirin monotherapy.
❓East Asian paradox
thelancet.com/journals/lance…
✅TALOS- AMI: De-escalation ✅
In pts w/ no major events in 1st month after index PCI, de-escalation of DAPT from #ticagrelor to #clopidogrel is superior to tica-only DAPT in terms of net clinical benefit, with
⬇️decreased bleeding 🩸risk
- no increase in ischaemic risk
#ACC21
In pts w/ no major events in 1st month after index PCI, de-escalation of DAPT from #ticagrelor to #clopidogrel is superior to tica-only DAPT in terms of net clinical benefit, with
⬇️decreased bleeding 🩸risk
- no increase in ischaemic risk
#ACC21
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
Very important and high-yield #AIBD2020 session with @UmaMahadevanIBD on #IBD in #pregnancy! 🤰🔥💩👶
⬇️⬇️⬇️
@IBDConference #GITwitter #GI #OBGYNtwitter #OBGYN
⬇️⬇️⬇️
@IBDConference #GITwitter #GI #OBGYNtwitter #OBGYN
Management of a healthy pregnancy begins... before pregnancy!
#AIBD2020 @IBDConference @UmaMahadevanIBD #IBD
#AIBD2020 @IBDConference @UmaMahadevanIBD #IBD
Start planning early!
Want 3 months of steroid-free remission before conception.
#AIBD2020 @IBDConference @UmaMahadevanIBD #IBD
Want 3 months of steroid-free remission before conception.
#AIBD2020 @IBDConference @UmaMahadevanIBD #IBD
With the .@NIAIDNews #ACCT1 trial final report published on 05 Nov 2020 and the .@WHO's #SolidarityTrial Preliminary report published on 02 December 2020, thought it would be good to take another look at both trials and find ways forward for the patients we are dealing with today
Motivated by a patient I am dealing with who will survive very severe #COVID19 in the setting of transplant, but her father, who was hospitalized earlier than her with moderate COVID, was left to progress and died before her discharge, given #remdesivir only after going on #BiPAP
Here is the link to the prior analysis and I think the new publications give some interesting details which will follow
9 common causes of heavy menstrual bleeding everyone should know
1. Fibroids
2. Pelvic infections
3. Drugs
4. Polyps
5. IUCDs
6. Endometriosis
7. Blood clotting problems
8. Cancers of the womb or cervix
9. Thyroid disease
A thread 🧵
{Share for awareness!}
1. Fibroids
2. Pelvic infections
3. Drugs
4. Polyps
5. IUCDs
6. Endometriosis
7. Blood clotting problems
8. Cancers of the womb or cervix
9. Thyroid disease
A thread 🧵
{Share for awareness!}
If a woman loses more than 80ml of blood in one period, the bleeding is heavy.
Although methods of quantifying the exact amount of blood loss are not usually accurate, most women know when their period is heavy & heavy usually often come with blood clots.
Although methods of quantifying the exact amount of blood loss are not usually accurate, most women know when their period is heavy & heavy usually often come with blood clots.
1
Nearly 20% of women over 30 years have #fibroids.
They are of different types & may cause heavy menstrual bleeding.
Treatment depends on the many factors. So see your doctor.
Nearly 20% of women over 30 years have #fibroids.
They are of different types & may cause heavy menstrual bleeding.
Treatment depends on the many factors. So see your doctor.
Good Day 🌎! Are you ready for one of Gods🌿to be Federally Legalized? I have stood strong on this since #DJT announced he would run in 2015. Follow along for my thoughts and leave a comment below. Please retweet and lets help those who need it most. #WWG1WGA
2) Starting off we know the issues with his brother and #Alcohol which for most would lead them to believe he was completely against any and all substances. However I am lead to believe the exact opposite.
THREAD: Split This! A TI tweetorial on pill splitting
1/ Split this! Pill splitting (dividing tablets into smaller doses)
Practical tips to help patients + their families make the most of their medications during the #COVID19 pandemic
#medication #pillsplitting #TIEvidence
1/ Split this! Pill splitting (dividing tablets into smaller doses)
Practical tips to help patients + their families make the most of their medications during the #COVID19 pandemic
#medication #pillsplitting #TIEvidence
2/ Split this! PILL SPLITTING can safely extend medication supplies longer, saving 💰💰 and 🚗 to the pharmacy
Most pharmacies carry pill splitters for as little as $5 😀
Consumer reports review: tinyurl.com/ycstbx2t
#medication #pillsplitting #TIEvidence
Most pharmacies carry pill splitters for as little as $5 😀
Consumer reports review: tinyurl.com/ycstbx2t
#medication #pillsplitting #TIEvidence
3/ Split This! #CHOLESTEROL-LOWERING DRUGS
Do you take 20mg of atorvastatin every day? Ask for 40mg tablets and split them, saving 💰💰 and 🚍 to the pharmacy
#medication #pillsplitting #TIEvidence #cholesterol
Do you take 20mg of atorvastatin every day? Ask for 40mg tablets and split them, saving 💰💰 and 🚍 to the pharmacy
#medication #pillsplitting #TIEvidence #cholesterol
Study warns against combined use of oral #anticoagulants , #antiplatelet therapy for #AFib 1️⃣
#GARFIELD-AF registry
escardio.org/The-ESC/Press-…
#GARFIELD-AF registry
escardio.org/The-ESC/Press-…
@ShawnMcGuirk @CFAMMcan @mcgillu @santecannabis @trinafraser #ACMPR highlights #WeedLikeToKnow :
- limit of <30-day supply or 150g
- LP delivery by mail only, no retail point of sale
- medical doc lasts 1 year
- storage limit (to be removed soon with #CannabisAct )
- Soon, might be able to transfer from one licensed producer to another
- limit of <30-day supply or 150g
- LP delivery by mail only, no retail point of sale
- medical doc lasts 1 year
- storage limit (to be removed soon with #CannabisAct )
- Soon, might be able to transfer from one licensed producer to another
@ShawnMcGuirk @CFAMMcan @mcgillu @santecannabis @trinafraser #CannabisAct Bill #C45 removes #cannabis from #cdsa, separate act will be created for regulation of cannabis
- Can grow up to 4 plants (debated) in dwelling
- legal limit up to 30g in public
- anticipate royal ascent by end of June, coming into force Sept/Oct 2018
#WeedLikeToKnow
- Can grow up to 4 plants (debated) in dwelling
- legal limit up to 30g in public
- anticipate royal ascent by end of June, coming into force Sept/Oct 2018
#WeedLikeToKnow
@ShawnMcGuirk @CFAMMcan @mcgillu @santecannabis @trinafraser There is still reluctance in prescribing #MedicalCannabis, and there is lack of point of sale (still will have to be by mail), excise tax and HST/GST upcoming, lack of drug plan coverage.
#WeedLikeToKnow #SPEforum
#WeedLikeToKnow #SPEforum
