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Hey #MedTwitter. @HannahRAbrams learned me lots about #asterixis and #HE. Some theories that have been posited by myself and my teams for causes of asterixis:
1. Inattention 2/2 encephalopathy - this would serve as common pathway for asterixis in HE, uremia and hypercarbia.
1. Inattention 2/2 encephalopathy - this would serve as common pathway for asterixis in HE, uremia and hypercarbia.
2. Toxic effects of ammonia on peripheral nerves - possible, but doesn't help unify the three main causes of asterixis.
3. Global cerebral slowing (what @HannahRAbrams found) - Similar to #1. Also it is suggested that other metabolic disturbances could cause this.
3. Global cerebral slowing (what @HannahRAbrams found) - Similar to #1. Also it is suggested that other metabolic disturbances could cause this.
It seems like there is proof of slowing in the motor cortex, so it is not just #1. But, for anyone who has cared for a patient with #HE, it is clear that attention is an issue. So maybe combo of #1 and #3? I haven't found evidence for #2.
