Discover and read the best of Twitter Threads about #at527
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Antiviral pills for #COVID19 may be available soon: 3 in clinical trials, results expected as soon as late fall/winter: Merck & Ridgeback Biotherapeutics’ #molnupiravir ; Pfizer’s #PF07321332, & Roche & Atea’s #AT527 usatoday.com/story/news/hea…
“only one antiviral drug, remdesivir, has been approved to treat #COVID. But it is given intravenously to patients ill enough to be hospitalized, & is not intended for early, widespread use. By contrast, the top contenders under study can be packaged as pills.”
“That would mean millions …could have access to a daily orally administered medication, ideally a single pill, that could be taken for five to 10 days at the first confirmation of #COVID19 infection”
First-in-Woman Safety, Tolerability, and Pharmacokinetics of Orally Administered #GS441524: A Broad-Spectrum Antiviral Treatment for #COVID19. A 🧵1/7 osf.io/am5s8/
Part 1 of the study: 750 mg GS-441524 was orally administered as a solution QD for 7 days. D1-5 were performed in the fasted state. D6-7 in the fed state. There was a slight food effect that seemed to hamper drug absorption. Cmax ~2.4-3 uM. AUC ~26-33 uM. 2/7 
No AEs or lab abnormalities were observed in Part 1 of the study. Blood chemistry was normal. 3/7
