Discover and read the best of Twitter Threads about #autoimmunity

Most recents (18)

“There is quite convincing documentation that supports that the MEtabolic energy turnover is disturbed by #ME. By metabolic energy MEtabolism we mean the biochemical processes in the body, that transform, distribute and utilize energy sources in the food👇🏻 forskersonen.no/cellebiologi-k…
“Oxygen is the most important single factor for the cells' production of the important energy molecule ATP. The oxygen consumption of the muscle cells increases dramatically during physical work, but it has a limit. As the oxygen supply becomes insufficient, 👇🏻 #PwME #MEcfs
the production of lactic acid (lactate) increases, and then the working capacity of the muscle will rapidly decrease.” #MEcfs #PwME #ImmunoMEtabolism #ATP #KrebsCycle
Read 21 tweets
Thyroid as a #target of adjuvant #autoimmunity /#infammatory syndrome due to mRNA‐based SC2 vaccination.
#Vaccines contain #adjuvants which are not exempt from adverse efects and can #trigger the autoimmune/infammatory syndrome induced by adjuvants (#ASIA). Image
Multiple endocrine organs have receptors for ACE2.
mRNA of ACE2, the SARS-CoV2 receptor, is expressed in the thyroid cells.
ACE2 receptor is abundantly expressed by the thyroid. Elevated levels of proinflammatory cytokines could increase the expression ofACE2 on the thyroidgland.
ASIA covers a wide range of diseases like macrophagic myofasciitis syndrome, post-vaccination phenomena, #GulfWar syndrome #GWS and Silicosis.
After mass vaccination with SARS-CoV2 vaccines, some cases of Graves’ disease have been reported. #Grave ‘s disease after #Pfizer.
Read 14 tweets
What happens if we allow #SARS2 to become endemic? What’s going to happen to us & what’s going to happen to the virus?

If we allow it to become endemic—and some would argue that it is already endemic—this does not mean that it is going to attenuate, not whatsoever. 1/
It is not true that more transmissible versions of #SARS2 will be more benign. What we are seeing is more aggressive, more transmissible versions which are creating more severe illness. And the virus is still adapting to our physiology. It’s doing it at a fantastic rate 2/
What we’re going to see is that it will continue to work against our immune systems, meaning become more immune evasive. It’s going to become more chronic as an infection. 3/
Read 14 tweets
Mark Davis now. He's talking about celiac (severe gluten intolerance/sensitivity). He found that gluten-specific CD4+ T cells were directly associated with the response. (1/6) #fatigue #celiac #autoimmunity
Interestingly, they're mentioning elevated KIR+ CD8+ cells in autoimmunity. KIR is typically thought of as a marker for NKCs, & associated with their maturation (me saying this, not M Davis). Intriguing, then, that KIR+ CD8+ cells are associated w/autoimmunity... (2/6) #fatigue
...when decreased function of NKCs is associated with ME/CFS. Moreover, perforin (a compound created by NKCs and often a way of measuring their functionality) (3/6) #MECFS #immunology #fatigue
Read 11 tweets
@MBVanElzakker and I are excited that our new paper on biological factors that may contribute to the development of LongCovid/PASC was published today: frontiersin.org/articles/10.33…
2/ The paper details mechanisms by which RNA #viruses beyond just #SARS-CoV-2 have be connected to long-term health consequences.
3/ It also reviews literature on acute #COVID-19 and other virus-initiated chronic syndromes such as post-#Ebola syndrome or #ME/CFS to discuss different scenarios for #LongCovid/#PASC symptom development.
Read 10 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
#CDC has recently reported myocarditis & pericarditis cases following #mRNA #vaccination in adolescents & young adults in the US. Are these the first reported cases of cardiac involvement following mRNA vaccines? 1/
cdc.gov/coronavirus/20…
Fortunately, these incidents are extremely rare events. But, have the agencies overlooked earlier signals? Are these cases indeed related to mRNA vaccines? Are the vaccines responsible? If yes, what could be the probable mechanism? 2/
Few cases of post-vaccination myocarditis, heart failure & heart attacks have been reported in #Israel since December soon after the launch of #Pfizer mRNA vaccine. Health officials referred them as “A murky wave of heart attacks” 3/
israelnationalnews.com/News/News.aspx…
Read 17 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
1/x Platelets Can Associate With SARSCoV2 RNA and Are Hyperactivated in C19 (17/9/2020)

Quoting,
“...HYPERCOAGULATION and THROMBOSIS contribute to lethality of [C19].
Platelets are chiefly implicated in thrombosis.
[platelets] CAN interact with viruses”

ahajournals.org/doi/full/10.11…
2/x Con’t quote,

“platelets hyperactivated in C19 subjects presenting nonsevere & severe symptoms,
with AGGREGATION occurring at suboptimal #thrombin concentrations

...platelets adhered more efficiently...

Platelets may...contribute to overwhelming THROMBO-INFLAMMATION in C19”
3/ Quoting

“[platelets] are an important source of inflammatory mediators.
While a LOWER PLATELET COUNT is associated with severity/mortality, little is known about platelet function during C19.”

Q:
What causes LOWER platelet count
and platelet AGGREGATION
in some C19 patients?
Read 190 tweets
This tweet thread is about the #Covid_19: Updates from Singapore webinar on 26 Feb 2021

I've been busy so this is ~ a month after

It will be followed by a tweet thread documenting a more recent episode that was last week
#Covid_19 : Updates from Singapore is a webinar organised by @WHOGOARN and @NUSMedicine

And moderated by @profdalefisher, Prof. David Allen, and Dr. Louisa Sun
We are joined tonight by Dr. Peter Karim Ben Embarek
Read 51 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
1/ This excellent study by @aaronmring/@VirusesImmunity and team found that COVID-19 patients exhibit dramatic increases in the production of antibodies against thousands of human extracellular and secreted proteins (the exoproteome) compared to controls 👇
2/ The million dollar question is: what molecular mechanisms underly this antibody/#autoantibody production? It is worth interpreting the findings via the lens of human #microbiome/#virome activity + the activity of persistent pathogens (such as EBV) harbored by study subjects.
3/ Every study subject harbored extensive microbiome/virome communities comprised of trillions of organisms during #COVID-19 infection…with such ecosystems now understood to persist beyond just the gut but also in other body sites (#lung, liver etc).
Read 15 tweets
Pedersen, N., Duricova, D., & Munkholm, P. (2009). Pulmonary Crohn's disease: A rare extra-intestinal manifestation treated with infliximab. Journal of Crohn's & colitis, 3(3), 207–211. doi.org/10.1016/j.croh…
Hayek, A. J., Pfanner, T. P., & White, H. D. (2015). Inflammatory bowel disease of the lung: The role of infliximab?. Respiratory medicine case reports, 15, 85–88. doi.org/10.1016/j.rmcr…
Read 10 tweets
Dear #NEISvoid/twitter, I am VINDICATED (&, uh, still hyper on steroids, FWIW). Awesome Sleep/RespDoc is of the educated &firm opinion (upon reviewing my hospital discharge summary, lung function test results...which the hospital still hadn’t passed on yet as of this morning? 🙄)
...that I have NOT suddenly & completely coincidentally managed to develop asthma for the first time in my life at the tender age of 39 (although he thinks it does sound like a bronchospasm cough, which is literally how I was describing it when it first started happening.
Nor do I seem to have any kind of lung problem, nor a recent past upper/lower resp tract infection). Although apparently he hadn’t received the results of either of the sputum culture tests from the hosp. I’m assuming they were boringly negative or I’d have heard by now, though.)
Read 37 tweets
@KylenH @bennessb Yes, I think so. I don’t have the super-soft/delicate/stretchy skin of EDS classic type,, & although I do get atopic dermatitis it seems to be different to the irritation & peeling skin I get from tape. I also get a particular (&, I think, related) skin reaction to anything that
@KylenH @bennessb rubs, including my otherwise-awesome thumb splints. Alsoalso very prone to skin tags in high-friction areas, fwiw. I don’t seem to have full-on #MCAS on anything, but I do wonder if #MastCellsGoneWild could be implicated somehow,
@KylenH @bennessb esp given my recent experiences of simultaneous #multisystemic #autoimmune #chronicillness affecting GI system (#IBD: #crohns but also #GORD), skin (#PyoG), joints (#AnkSpond/#spondylarthropathy/ seronegative #arthritis) & prob aspects of the respiratory system
Read 9 tweets
Definitely has not yet properly sunk in that - if how I am right now is roughly what my baseline level of energy/PEM/ pain/other sx/digestion should be - then...basically I never properly recovered from that #crohns flare in 2014 that my now-former gastro said wasn’t a flare. 🥺
(I know it’s partly the #corticosteroids. I KNOW. But everyone at the hospital was keen to reassure me that it isn’t ONLY the steroids, & the difference in my previously-unnoticed levels of gut pain & the truly ridiculous levels of malabsorption alone is... kind of staggering.)
I am SO MUCH LESS #ActuallyAutistic-mode anxious & so much more functional than usual &I'm trying not to have an emotional explosion over it bc I'd been like ~that~ for sooo long by now I think I’d almost forgotten that I haven't actually been like that my entire adult life! 🤯😭
Read 9 tweets
@FandomjunkieZee @bennessb Clinical depression, seronegative arthritis/#spondylarthropathy, food intolerances (although I needed help working out the specifics), #EDS, #POTS, #endometriosis, #ActuallyAutistic, #PyoG. Thankfully in the latter case I only had a STRONG HUNCH for days before dx was confirmed.
@FandomjunkieZee @bennessb @threadreaderapp unroll, danke schön! 😄
Read 3 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!