Discover and read the best of Twitter Threads about #avrm2019bris
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☣First up for the final session is ☣Nathan Bartlett (ncbi.nlm.nih.gov/pubmed/?term=B…), Hunter Medical Research Institute, Uni of Newcastle, NSW talking on TLR2 agonist treatment suppresses rhinovirus infection of human epithelial cells in vitro
#ARVM2019Bris
#ARVM2019Bris
☣modify host immunity to tackle *any* virus; boost innate immunity
☣grand plan
☣TLR the sentinel activators/regulators of innate immunity
☣any old virus can be a huge problem if you are immunosuppressed (vax less effective)
#ARVM2019Bris
☣grand plan
☣TLR the sentinel activators/regulators of innate immunity
☣any old virus can be a huge problem if you are immunosuppressed (vax less effective)
#ARVM2019Bris
☣TLRs on the surface facing out, and those inside in endosomes (the antiviral TLRs) inducing lots of IFN and inflammation
☣used as a last resort to avoid immunopathology that can be associated with their activation; too inflammatory
#AVRM2019Bris
☣used as a last resort to avoid immunopathology that can be associated with their activation; too inflammatory
#AVRM2019Bris
