Discover and read the best of Twitter Threads about #bacteriophage

Most recents (3)

We are delighted to announce the release of #PhageAI 0.10.0: extended repository and the new #phage #prediction tool: #chronic #lifecycle. 1/4
Each of the #phage genome has computed a new numerical vector representation by #Phage2Vec technology, re-classified #lifecycles and re-computed nearest neighborhood what introduced updated alignment-free top-10 similar #bacteriophages registry. 2/4
Furthermore, we released beta #bacteriophage #taxonomy #prediction tool.

Feel free to extend your account role from basic to Expert user using "My Profile" view, to access it from the @PhageAI. 3/4
Read 4 tweets
Article says 97% of new drugs tested for cancers never make it to market 👉 IMO key to better #cancer therapies will require widespread recognition of the tumor #microbiome/virome...+ the fact that pathogens in such communities can drive changes in #tumor gene expression
Good example of the trend 👉 “Our study demonstrates that #pancreatic adenocarcinoma (PDAC) #microbiome composition, which cross-talks to the gut microbiome, influences the host immune response and natural history of the disease.” cell.com/cell/fulltext/… ImageImage
Or 👉 “...these data indicate that microbial DNA is present in the #breast and that #bacteria or their components may influence the local immune microenvironment. Our findings suggest a previously unrecognized link between dysbiosis and breast cancer”: journals.plos.org/plosone/articl… ImageImage
Read 5 tweets
Microbes/viruses interact to drive disease 👉 Here, a #bacteriophage (Pf) that infects bacterial pathogen p. aeruginosa (Pa)☝️promoted Pa virulence (in wounds) by triggering maladaptive anti-viral responses in human cells + suppressing bacterial clearance: science.sciencemag.org/content/363/64…
In addition 👉 1. The data suggest that a natural (unmodified) #bacteriophage may be able to produce mRNA within human cells☝️2. Consistent with a pathogenic role for Pf #phage, a vaccine against Pf phage protected against P. aeruginosa wound infections in mice
Simple summary 👉 This marks the first time a #bacteria-infecting #virus, otherwise known as a #bacteriophage...has been observed inducing the immune system to mount an antiviral response and, in doing so, causing it to ignore the bacterial infection: google.com/amp/s/medicalx…
Read 3 tweets

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