Discover and read the best of Twitter Threads about #bcells
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✨ We're delighted to present a new Special Issue on Human #Bcells!
Guest edited by @BemarkMats, @JoSpencerLab & @Thomas_J_Tull, this collection explores the complexity of #Bcell development & function
Explore the articles below 🧵 & read for free ➡️bit.ly/40O6Onh
1/10
Guest edited by @BemarkMats, @JoSpencerLab & @Thomas_J_Tull, this collection explores the complexity of #Bcell development & function
Explore the articles below 🧵 & read for free ➡️bit.ly/40O6Onh
1/10
As well as #Bcell subtypes in health & inflammatory diseases, this collection also examines aspects of B cell diversity depending on #immunoglobulin isotype & in a microanatomical context
Our guest editors introduce the series in this Editorial 👇 2/10
academic.oup.com/cei/article/21…
Our guest editors introduce the series in this Editorial 👇 2/10
academic.oup.com/cei/article/21…
Rebekah Velounias & @Thomas_J_Tull @KCLImmunoMicro kick off the series papers with a discussion of B cell subset classification & their changes in #inflammatory disease 3/10
academic.oup.com/cei/article/21…
academic.oup.com/cei/article/21…
A great paper by Dr. @SaraSuliman13 on her work with Dr. Luo on #tuberculosis in #Peruvians: nature.com/articles/s4146… #BIIW21 #BIIAtTheBench
#GWAS can be hard to link genes together and that's okay. This means we need to regroup #BIIW21 #BIIAtTheBench
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
Our first paper authors.elsevier.com/a/1cRqD6tu0Cbo… is now out @CellStemCell! With @ionispharma & the Jamieson Lab @UCSanDiegoDRM, we found that selective #antisense oligonucleotides inhibiting #IRF4 reduce disease burden & #multiplemyeloma #regeneration in #cancer models. @CellPressNews 1/
IRF4 (interferon regulatory factor 4) is a key plasma cell transcription factor that is known to play a critical role in #myeloma progression. It's been shown to activate networks of #cellcycle and cancer regulators, including the notorious #cancer and #stemcell gene, #MYC. 2/
In this new work, the talented @PhoebeMondala & @AshniVora first dug deeper into the IRF4 networks activated in high-risk forms of #myeloma, including #plasmacellleukemia. IRF4 target genes (SLAMF7, BCMA) were widely induced, especially among genes regulating the #cellcycle. 3/
Just a thought: When we discuss #COVID19 severity varying in response to the dose of viral exposure, that likely also has a temporal component. 1/?
As in, clearing a virus from the body requires a coordinated response from multiple arms of the immune system, each of which takes different amounts of time to ramp up. Early innate response is quick, but largely incapable of responding to exponential growth. 2/?
So being exposed to a large dose of virus at once could lead to a hyperreactive innate response that causes exaggerated adaptive immune responses down the line. 3/?
I recommend reading about immunological synapses to better understand how various immune cells (particularly T cells and NK cells) can grab onto antigens and aid B cells in maturing higher affinity BCRs and antibodies, as well as encourage division
en.m.wikipedia.org/wiki/Immunolog…
en.m.wikipedia.org/wiki/Immunolog…
CD8+ “Killer” T cells: jcs.biologists.org/content/129/15…
B cells and CD4+ Th cell mediated antibody formation and B cell activation:
step1.medbullets.com/immunology/105…
step1.medbullets.com/immunology/105…
