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Good morning science Twitter 😁🧬🔬 Our deep profiling of human IL-10-producing B cells by single-cell, highly multiplexed cytometry analysis is live on @biorxivpreprint! #bcellsrule
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As all you immunology researchers know well, Tregs are the 'popular' lymphocytes when it come to regulatory immune cells. Yet, there is provocative evidence that regulatory B cells (#Bregs) also mediate anti-inflammatory function, primarily through production of #IL10.
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Many knowledge gaps remain with respect to the optimal signals to induce Bregs, their phenotypic and functional diversity across healthy humans, and the potential of canonical B cell subsets to give rise to IL-10-producing cells.
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