Discover and read the best of Twitter Threads about #bcma
Most recents (3)
The #AACR23 abstracts will be accessible from here (not all sessions populated yet at the time of this tweet)
abstractsonline.com/pp8/#!/10828/
abstractsonline.com/pp8/#!/10828/
"new drugs on the horizon":
ND03 - Discovery of ARV-766, an androgen receptor degrading PROTAC for the treatment of men with metastatic castration resistant prostate cancer $ARVN #PROTAC
abstractsonline.com/pp8/#!/10828/pโฆ
ND03 - Discovery of ARV-766, an androgen receptor degrading PROTAC for the treatment of men with metastatic castration resistant prostate cancer $ARVN #PROTAC
abstractsonline.com/pp8/#!/10828/pโฆ
ND01 - ABBV-319: A first-in-class Glucocorticoid Receptor Modulator (GRM) agonist #ADC for the treatment of B-cell malignancies $ABBV
abstractsonline.com/pp8/#!/10828/pโฆ
abstractsonline.com/pp8/#!/10828/pโฆ
@jmikhaelmd @BonumCe @JanssenUS @pfizer 2/ ๐๐ AMA PRA Credit ๐
CME โน๏ธ & ref list๐ bit.ly/3DtOjtZ
๐๏ธ Disclosure info ๐
#BonumCE #MMSM
CME โน๏ธ & ref list๐ bit.ly/3DtOjtZ
๐๏ธ Disclosure info ๐
#BonumCE #MMSM
@jmikhaelmd @BonumCe @JanssenUS @pfizer 3/๐ซTaking off...
๐ค#biomarker definitions
๐ฏDx biomarkers distinguish๐ฅw disease &๐ฅ w/o
๐ฎPrognostic biomarkers forecast likelihood of a clin event, dz progression or recurrence
๐ฎPredictive biomarkers identify ๐ฅ more likely to experience favorable/unfavorable effect from ๐๐
๐ค#biomarker definitions
๐ฏDx biomarkers distinguish๐ฅw disease &๐ฅ w/o
๐ฎPrognostic biomarkers forecast likelihood of a clin event, dz progression or recurrence
๐ฎPredictive biomarkers identify ๐ฅ more likely to experience favorable/unfavorable effect from ๐๐
@jmikhaelmd @BonumCe @JanssenUS @pfizer 4/ ๐ #BonumCE #MMSM
SP is 63 yo/M presents w anemia & bone pain
BMBX shows 70% clonal plasma cells and FISH reveals t(11;14)
MRI shows multifocal bone lesions
sBCMA is 227 ng/mL and SLAMF7 8.3 ng/mL by ELISA
โ๏ธ Which is diagnostic of #multiplemyeloma in SPโ
SP is 63 yo/M presents w anemia & bone pain
BMBX shows 70% clonal plasma cells and FISH reveals t(11;14)
MRI shows multifocal bone lesions
sBCMA is 227 ng/mL and SLAMF7 8.3 ng/mL by ELISA
โ๏ธ Which is diagnostic of #multiplemyeloma in SPโ
Ten #ASH20 #MultipleMyeloma abstracts that I think will most inform my clinical practice [๐ป๐๐๐๐๐
] #1/11 #mmsm
1. Another trial [๐ญ๐ถ๐น๐ป๐ฌ] shows meaningful PFS benefit with early ASCT [after KRD], irrespective of cytogenetic risk. (Despite similar early MRD-negative rates in both arms) tinyurl.com/y4re2gpw #mmsm 2/11
2. Long-term follow-up of bb2121 [Ide-Cel] at a median of 15 months: Median PFSโก๏ธ๐ ๐ฆ๐จ๐ง๐ญ๐ก๐ฌ. At 450 x 106 dosing, โ80% โฅVGPR and โ40% CR. Hope to get @FDAOncology approval soon?? tinyurl.com/y4lwcvjy #mmsm 3/11
