Discover and read the best of Twitter Threads about #bcma

Most recents (3)

The #AACR23 abstracts will be accessible from here (not all sessions populated yet at the time of this tweet)
abstractsonline.com/pp8/#!/10828/
"new drugs on the horizon":

ND03 - Discovery of ARV-766, an androgen receptor degrading PROTAC for the treatment of men with metastatic castration resistant prostate cancer $ARVN #PROTAC
abstractsonline.com/pp8/#!/10828/pโ€ฆ
ND01 - ABBV-319: A first-in-class Glucocorticoid Receptor Modulator (GRM) agonist #ADC for the treatment of B-cell malignancies $ABBV
abstractsonline.com/pp8/#!/10828/pโ€ฆ
Read 42 tweets
@jmikhaelmd @BonumCe @JanssenUS @pfizer 2/ ๐ŸŽ‡๐Ÿ†“ AMA PRA Credit ๐ŸŽ‡
CME โ„น๏ธ & ref list๐Ÿ‘‰ bit.ly/3DtOjtZ
๐Ÿ—๏ธ Disclosure info ๐Ÿ‘‡
#BonumCE #MMSM Image
@jmikhaelmd @BonumCe @JanssenUS @pfizer 3/๐Ÿ›ซTaking off...
๐Ÿค”#biomarker definitions
๐ŸŽฏDx biomarkers distinguish๐Ÿ‘ฅw disease &๐Ÿ‘ฅ w/o
๐Ÿ”ฎPrognostic biomarkers forecast likelihood of a clin event, dz progression or recurrence
๐Ÿ”ฎPredictive biomarkers identify ๐Ÿ‘ฅ more likely to experience favorable/unfavorable effect from ๐Ÿ’Š๐Ÿ’‰ Image
@jmikhaelmd @BonumCe @JanssenUS @pfizer 4/ ๐Ÿ“Š #BonumCE #MMSM

SP is 63 yo/M presents w anemia & bone pain
BMBX shows 70% clonal plasma cells and FISH reveals t(11;14)
MRI shows multifocal bone lesions
sBCMA is 227 ng/mL and SLAMF7 8.3 ng/mL by ELISA

โ˜‘๏ธ Which is diagnostic of #multiplemyeloma in SPโ“
Read 25 tweets
Ten #ASH20 #MultipleMyeloma abstracts that I think will most inform my clinical practice [๐‘ป๐’‰๐’“๐’†๐’‚๐’…] #1/11 #mmsm
1. Another trial [๐‘ญ๐‘ถ๐‘น๐‘ป๐‘ฌ] shows meaningful PFS benefit with early ASCT [after KRD], irrespective of cytogenetic risk. (Despite similar early MRD-negative rates in both arms) tinyurl.com/y4re2gpw #mmsm 2/11
2. Long-term follow-up of bb2121 [Ide-Cel] at a median of 15 months: Median PFSโžก๏ธ๐Ÿ— ๐ฆ๐จ๐ง๐ญ๐ก๐ฌ. At 450 x 106 dosing, โ‰ˆ80% โ‰ฅVGPR and โ‰ˆ40% CR. Hope to get @FDAOncology approval soon?? tinyurl.com/y4lwcvjy #mmsm 3/11
Read 12 tweets

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