Discover and read the best of Twitter Threads about #biccn
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Olfactory sensory neurons (OSNs) use transcription to make flexible predictions about the environment and dynamically change odor responses, now in our new paper led by the amazing @TatsuyaTsuka0 and @davidhbrann! Thread about what we found 👉1/n bit.ly/3pGvY6u
Mammalian OSNs are thought to more or less faithfully tell the brain about what they are detecting via their odor receptors (OR), suggesting that the brain is largely responsible for sorting novel, salient cues from predictable background signals 2/n
In this view OSNs are empty vessels for OR expression, whose response properties solely arise from the single receptor (of ~1000) they express. This is (in part) why folks use heterologous expression or empty neuron-type systems to characterize OR responses to odor 3/n
The 17 #BICCN @nature papers on the primary motor cortex in mouse (+some human & marmoset) that were published yesterday are a major step forward in terms of open science for an @NIH consortium. For reference, links to the open access papers are here: nature.com/collections/ci… 1/🧵
First, the #BICCN required preprints of all the papers to be posted on @biorxivpreprint, and as a result the papers were already online 1-1.5 years ago. Of course the final versions now published have been revised in response to peer review. 2/
Speaking of peer review, almost all the papers were published along with the reviews. In combination with the preprints, this provides an unprecedented view of how consortium work is reviewed and how authors respond. Real data for this perennial debate: 3/
