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New paper @pai_vaibhav: onlinelibrary.wiley.com/doi/10.1111/wr… #bioelectric repair of eye, heart, and gut defects from a range of chemical teratogens and even from mutations of a key neurogenesis gene Notch! Molecular or drug (human-approved) methods repair defects in multiple germ layers. 🧵:
Super excited about this; here's context of how we got here via Pai's prior papers, & ties of this biomed-focused project to basal cognition field. Regulative development or regeneration needs to be able to ascertain correct vs. incorrect morphologies. How could cell groups do
that? Model nature.com/articles/s4159… but basically, think of image recognition by visual systems - can other body tissues act like retinas to process bioelectric info? We originally looked at the voltage prepatterns in the nascent frog brain and saw that teratogens screw up brain
