Discover and read the best of Twitter Threads about #bioenergetics
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New paper in @NatureMedicine on #mtDNA variant effects on metabolites, from my colleagues and I from @sangerinstitute, @emblebi , @Cambridge_Uni and @MRC_MBU! nature.com/articles/s4159…
@nicolesoranzo @cam_mito @OliverStegle @auroradevea @joannahowson @DoingYonova
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@nicolesoranzo @cam_mito @OliverStegle @auroradevea @joannahowson @DoingYonova
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We identified common #mtDNA variants in 16K British individuals with EUR ancestry from the INTERVAL study, performed the first large-scale assoc study between #mtDNA variants and ~5000 molecular traits that directly tag metabolic processes. 2/n 
We found and replicated significant associations between #mtDNA variants in Haplogroups Uk (found in 10% of the EUR population) and H3 (2%) and levels of N-formylmethionine (fMet), an amino acid known to be important for intra-mitochondrial translation. 3/n
