Discover and read the best of Twitter Threads about #biofilms

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🧵 "Images as Social Agents and Historical Ledgers in Knowledge Systems"

Today's SFI Seminar by @JSMF Fellow @onuhgrrarrow (@ASU) on how the co-evolution of images and concepts has shaped human knowledge about biological entities like cells & biofilms 🦠

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"Scientific images are inseparable from the complex knowledge systems in which they emerge...images are intermediaries between researchers and their concepts."
- @onuhgrrarrow (@ASU), streaming now:

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"In the late 19th Century, the first biology textbooks were getting published. In them, all the images of cells were of *specific* cells. A little later the pictures are of slightly diagrammatic cells. Finally, fully diagrammatic."

- @onuhgrrarrow (@ASU):
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Read 6 tweets
Here it is!

#Inktober2020 day 1 in my #PathogenPortraits series. After years of studying this in cow bums, it had to be #EcoliO157

It causes bloody diarrhoea & if that wasn't bad enough, sometimes kidney failure & death. More info @
nhsinform.scot/illnesses-and-…
#sciart #microbiology Inktober2020 E. coli O157 c...
#Inktober2020 day 2 in my #PathogenPortraits series. 'The Clap' (Neisseria gonorrhoeae) b/c who doesn't 💚 green purulent discharge?

It's sexually transmitted but also from mother->newborn during birth to cause blindness.
More info: microbewiki.kenyon.edu/index.php/Neis…

#sciart #microbiology Image
#Inktober2020 day 3 in my #PathogenPortraits series. The very 💛golden💛 #MRSA.

Minds it's own business on your skin, but if it gets inside, methicillin won't do a thing to stop it.

More info at mrsaactionuk.net/MRSA.html #sciart #microbiology Methicillin resistant staph...
Read 34 tweets
For my M.S. thesis, I studied ways to disrupt #biofilms - individual bacteria cells that come together & form a community that is up to 1000 times more resistant to antibiotics!
Biofilm formation is kind of like when 10 individual people (bacteria cells) come together & tightly lock arms to form a group (biofilm). You can imagine, it's much harder to knock over a group of 10 people than 1 person by them self. This is how bacteria mobilize under stress.
Biofilms are a perfect example of how diverse communities thrive. The cells in a biofilm are all doing different things to ensure survival.

I asked the question - how is biofilm formation regulated? Can we genetically manipulate bacteria to change how biofilms form?
Read 4 tweets
Yes! For example this team showed that exposure to Wi-Fi radiofrequency #radiation for 5 hours modulated E. coli gene expression (52 #genes were upregated, 49 downregulated) 👉 that led to changes in several bacterial cellular + metabolic processes: nature.com/articles/s4159… ImageImage
2/ This study found that exposure of E. coli #bacteria to 2.4 GHz Wi-Fi radiofrequency radiation increased their antibiotic resistance and motility 👉 Moreover, #biofilm formation was enhanced in E. coli, S. aureus + Staph epidermis: europepmc.org/articles/pmc68… ImageImage
3/ It’s worth noting that bacterial communication in #biofilms is partly mediated by ion channel mediated #electrical signaling (even over long distances) 👉 Check out this interview I did w/ UCSD’s Gurol Suel on the topic: microbeminded.com/2018/01/29/20-… Image
Read 3 tweets
@jenbrea Hey! Yes several people spoke on that topic at the recent #ILADs conference I was at 👉 and remember this case history which found that a woman treated w/ antibiotics to target persistent #Bartonella had substantial improvement in EDS symptoms: ncbi.nlm.nih.gov/pmc/articles/P…
@jenbrea 2/2 As for #mast cell activation in response to persistent #pathogens...there is extensive literature on how a range of bacterial, viral and fungal pathogens can drive #MCAS-like symptoms 👉 for example: ncbi.nlm.nih.gov/pmc/articles/P…
@jenbrea 3/3 There is even a receptor common in #connective tissue who’s activity controls mast cell activation in response to bacterial signaling molecules that drive #biofilm formation: ncbi.nlm.nih.gov/m/pubmed/31278…
Read 11 tweets

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