Discover and read the best of Twitter Threads about #biogerontology
Most recents (2)
New paper on the evolution of #aging out! The first systematic review of the presence of the various known mechanisms of aging across the tree of life, the goal being to provide #geroscience and #biogerontology with a more solid framework. 1/10
frontiersin.org/articles/10.33…
frontiersin.org/articles/10.33…
The evolution of aging has been addressed at a general or theoretical level by major scientists, but no one had tried yet to address the basic question of the order of apparition of the various mechanisms of aging during evolution, with a focus on human aging. 2/10
The paper is based on a common hypothesis on the order of clades from cellular organisms to bilaterians. It also starts with the well-known hallmarks of aging but proposes a more precise decomposition into 20 specific hallmarks of aging (instead of the 9 generic hallmarks). 3/10
“The aging organism may also be viewed as a system with chemical fluctuations caused by biological reactions in the organism. This notion takes the whole organism as collected microscopically ordered patterns resembling oscillating chemical reactions.”
5 👍for correct author ID!
5 👍for correct author ID!
“In such reactions, the chemicals involved form a dissipative structure far from the equilibrium, which allowed the raw materials to be transformed to maintain as a certain self‐assembled biological structure that is ordered both spatially and temporally.....
However, it is harder to maintain such structures when the biological organization of an organism is constrained by its own biology and the genome evolution needed to maximize fitness, and is further impacted by age‐related changes...”
