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We are really excited that our work showing how pervasive lesion segregation shapes cancer genome evolution is published today in @nature.
nature.com/articles/s4158…
Here’s a #tweetorial to explain our #LesionSegregation findings...
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nature.com/articles/s4158…
Here’s a #tweetorial to explain our #LesionSegregation findings...
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Human cancer genomes are unavoidably confounded by genetic and environmental differences. Such intrinsic heterogeneity hinders our ability to disentangle biases of DNA damage and repair. So we used an in vivo oncogenesis model to re-run cancer evolution hundreds of times.
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WGS of mutagen-initiated tumours showed a high burden of point mutations, comparable to human cancers caused by exogenous mutagens, e.g. lung and skin cancer. The tumours are dominated by thymine mutations (“DEN signature”) and driver mutations in the EGFR-RAS-RAF pathway.
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