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Years ago we discovered that FGFR3 alterations are linked with a non-T cell-inflamed immune microenvironment in urothelial #BladderCancer #blcsm (1/6) cancerimmunolres.aacrjournals.org/content/early/… 
This finding was replicated in other data sets and suggested that FGFR3-active tumors may be less likely to respond to anti-PD1/L1 #Immunotherapy. It provided a strong rationale for combining FGFR inhibitors with anti-PD-L1 immunotherapy. (2/6)
This hypothesis was refined further by elegant data from @MattGalsky et al, which incorporated TGF-beta and EMT/stromal signatures, which further supported combining FGFR inhibitors and anti-PD-1/L1 (3/6) europeanurology.com/article/S0302-…
