Discover and read the best of Twitter Threads about #bog22
Most recents (2)
1/ We've just finished 3 papers on #transposons #infection #epigenomics #graphGenomes, the result of an amazing collaboration with @LB_Barreiro and Tomi Pastinen. Start of a long 🧵 
2/ The first paper by lead author @katiearacena is:
Epigenetic variation impacts ancestry-associated differences in the transcriptional response to influenza infection
tinyurl.com/ytvrk5hn
Epigenetic variation impacts ancestry-associated differences in the transcriptional response to influenza infection
tinyurl.com/ytvrk5hn
3/ @LB_Barreiro just talked about this paper at #BoG22 and @katiearacena has a poster so I'll let them explain their results!
In work led by Carrie Zhu, we consider some puzzles that arise in evaluating autosomal gene-by-sex interaction (GxSex) in complex human traits.
We argue that polygenic GxSex may be pervasive but largely missed by current approaches.
biorxiv.org/content/10.110…
1/n
We argue that polygenic GxSex may be pervasive but largely missed by current approaches.
biorxiv.org/content/10.110…
1/n
Should we polygenic effects to depend on context? In other organisms, where the environment can be controlled / manipulated, we know gene-by-environment interaction is the rule, not the exception. 2/n
What about sex as the context? A lot of traits are sexually dimorphic; but should we expect the causes to be sex-specific genetic effects? And to be found in existing, common genetic variation? Evidence from GWAS has been largely underwhelming. 3/n
