Discover and read the best of Twitter Threads about #bradykinin

Most recents (3)

#NEFlive #Notfallmedizin #Kasuistik #FOAM

der RTW und das NEF werden in eine zahnarztpraxis mit der einsatzmeldung "anaphylaxie" alarmiert. im behandlungsraum liegt eine 24-jährige patientin mit einem geschwollenen gesicht insbesondere der lippen und massiver atemnot. (1/16)
der zahnärztliche kollege gibt an, dass er der patientin für eine wurzelbehandlung lidocain appliziert und dann nochmal kurz den behandlungsraum verlassen habe. die ZFA habe ihn nach wenigen minuten gerufen, da das gesicht der patientin angeschwollen sei. (2/16)
die schwellung imponiert vor allem in der unteren gesichtshälfte und an den lippen. die zunge ist nur leicht geschwollen. wir hören einen inspiratorischen stridor. die atemfrequenz liegt bei 18/min. das pulsoxy zeigt eine SpO2 von 96% und eine herzfrequenz von 110 bpm. an. (3/16)
Read 17 tweets
1/n Continuing the discussion of the #bradykinin hypothesis, from the old thread ()
2/n You'll have to be a real multiplex cycle geek to like the next couple of tweets, but I'll get back to keeping it simple after those next tweets.

From Figure 2 of the paper,, when the renin–angiotensin system (RAS) system goes wonky, it gets complex
3/n Click on the pix to enlarge; read the paper. The aim of these overly geeky tweets is to be able to explain soon the important bits simply. The below is just an aid to understanding the above.
Read 9 tweets
THREAD from the new #bradykinin research (pre-print) from 🇳🇱:

"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."

#COVID19 #kinins…
➡️"the B1 receptor on endothelial cells is upregulated by proinflammatory #cytokines

➡️ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"


#bradykinin #COVID19
➡️"... and might explain the typical #CTscans and the feeling of people that they drown.

➡️In some pt., this is followed by a clinical worsening of disease around day 9 due to the formation antibodies directed against the spike (S)-antigen of #SARSCoV2 that binds to #ACE2"
Read 12 tweets

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