Discover and read the best of Twitter Threads about #cDCs

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#location location location: thrilled to share our work @CellCellPress! #interferons dictate #COVID19 severity! Specific #IFNs are produced along the #airways in response to #SARSCoV2 and drive protective or detrimental #transcriptional programs! 1/7 doi.org/10.1016/j.cell…
IFNs are driven by high #viral #loads, suggesting that viral recognition is only achieved when #SARSCoV2 reaches a certain threshold! Efficient induction of protective IFNs is preferentially achieved by younger patients, further explaining susceptibility of elders to #COVID19 2/7
#IFNL1 & #IFNL3 characterize mild illness & drive potent anti-#SARSCoV2 #ISGs in the upper #airways. Severe patients show #typeI IFN & #IFNL2 along the respiratory tract but lack ISGs, dampen cell proliferation programs associated to #repair and boost #apoptotic #p53 pathways 3/7
Read 7 tweets
HHS Paul Mango: Dealing in a world of uncertainty with #COVID19 #vaccines.
Don't know timing, quantity.
Different storage; some 1 dose, some 2 dose; Different days apart.
This is really a quite extraordinary logistically uncertainty
We are prepared for all of those uncertainties.
#WarpSpeed Paul Ostrowski: Doesn't do any good to have safe/effective #COVID19 #vaccines if can't distribute them
#WarpSpeed Paul Ostrowski: Control: We absolutely positively have to have control over each of these #vaccines as they are distributed.

[Cue Janet Jackson]

#COVID19
Read 64 tweets

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