Discover and read the best of Twitter Threads about #camostat

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Direi un fantastico contributo del team @CVRinfo guidato da @emcat1: in questo thread viene dimostrato come #OmicronVariant possa aver cambiato il modo in cui entra all'interno della cellula. Interessantissimo. Partiamo.
1/n 🧵…
#SARSCoV2 può entrare in due modi, entrambi richiedono l'attivazione della spike da parte delle proteasi.
1°: fusione della superficie cellulare, innescata da serina proteasi TMPRSS2.
2°: fusione endosomiale, innescata dalle catepsine. Finora SARS-CoV-2 ha seguito la 1°. 2/n
A tal proposito, è stato possibile utilizzare #pseudotipi di linee cellulari in cui predominano l'una o l'altra o entrambe le modalità. Come controllo (Pangolin CoV) che segue esclusivamente la 2° via. L'infezione da #Omicron è ben più importante quando la 2° è percorribile. 3/n
Read 10 tweets
OK so let's talk about camostat, because I'm starting to worry about it as a #COVID19 repurposing candidate. It emerged based on this Cell paper, but a LOT of assumptions are buried in the science.… Image
That Cell paper calls camostat "calls camostat “a clinically proven inhibitor of the cellular serine protease TMPRSS2” – which is not strictly correct.

It’s a clinically used drug (in Japan)

It has been shown to act on TMPRSS2 indirectly

Separate points. @Dereklowe
So what is camostat used for?

It's a serine protease inhibitor, and in Japan it's approved for treating pancreatitis. In that indiciation, doses are 600 mg are given. Data indicates it acts via anti-inflammatory action:…
Read 14 tweets
This is a thread on use of drugs for #COVID19
Hydroxychloroquine (Lupus, RA) Lopinavir/Ritonavir (HIV/AIDS) Remdisivir and Favipiravir (Ebola) and Camostat (Pancreatitis, Japan) are drugs that seem to have activity against SARSCov2
Some of these are used on Emergency Basis. 1/n Image
Potent nucleoside antiviral drug from Emory University shows broad spectrum activity against corona viruses including Remdisivir resistant strains. Acts by targeting RdRp to increase RNA mutation rates. @EmoryUniversity #EIDD2801 #COVID19
#coronavirus 1/n… ImageImage
Promising broad spectrum antiviral agent #EIDD2801 is active against #Remdisivir resistant strains. Indeed such mutations increase susceptibility which augurs well for combination use. It’s a prodrug gets converted to #EIDD1931 & increase mutations.
Read 4 tweets

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