Discover and read the best of Twitter Threads about #cancermetabolism
Most recents (1)
1/
In 1920, Dr. Otto Warburg wrote the best grant request ever: "Request. I need 10,000 Mark."
In 1920, Dr. Otto Warburg wrote the best grant request ever: "Request. I need 10,000 Mark."
2/
The request was granted and in 1924 he decided to thinly cut and mount slices of rat tumor in Ringer solution. He then measured lactic acid (lactate) production.
The request was granted and in 1924 he decided to thinly cut and mount slices of rat tumor in Ringer solution. He then measured lactic acid (lactate) production.
3/
Why? Well in 1863, Pasteur showed that a hypoxic environment induced the fermentation of sugars. Warburg essentially wanted to determine how tumors respire. It would follow that in a hypoxic environment, tumors would produce lactate.
Why? Well in 1863, Pasteur showed that a hypoxic environment induced the fermentation of sugars. Warburg essentially wanted to determine how tumors respire. It would follow that in a hypoxic environment, tumors would produce lactate.
