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SARSCoV2 trajectory toward #Omicron is AFAIK 1st 🥇 example of science watching trajectory of viral evolution to fulfill #CanyonHypothesis (more closed entry protein that hides receptor binding domain from antibodies). Beginning of pandemic was opposite: S became more “open” 👇👇
The #CanyonHypothesis was first put forth by the late Michael G Rossmann, a prominent viral structural biologist who died in May 2019. Anyone interested in SARS-CoV-2 Spike evolution should read the paper. Nothing short of prophetic pubmed.ncbi.nlm.nih.gov/2670920/ 
