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Treatment w/SGLT-2, what can & can’t the wonder drugs do 🤷🏻♀️
✅⤵️plasma&interstitial💦
✅⤵️❤️filling pressures&LV remodeling
✅⤴️♥️energy by ⤴️ ketogenesis👉🏻 shift♥️fuel from glucose👉🏻 ketones
✅⤴️erythropoietin👉🏻⤴️RBC ➕⤴️HCT👉🏻⤴️♥️02💨delivery
🛑SGLT-2 do NOT 👇🏻read below👇🏻🛑
✅⤵️plasma&interstitial💦
✅⤵️❤️filling pressures&LV remodeling
✅⤴️♥️energy by ⤴️ ketogenesis👉🏻 shift♥️fuel from glucose👉🏻 ketones
✅⤴️erythropoietin👉🏻⤴️RBC ➕⤴️HCT👉🏻⤴️♥️02💨delivery
🛑SGLT-2 do NOT 👇🏻read below👇🏻🛑
In pts WITHOUT hyperglycemia
⤴️diuresis does not occur👉🏻effects on renal volume excretion is dependent on the threshold of glucose in the nephron
📖DAPA-HF trial👉🏻NO ❌ reduction in diuretic req w/ ➕ of dapaglizflozin
✅ 15% ⤵️in BNP👉🏻LOWER effect size compared w/loops alone
⤴️diuresis does not occur👉🏻effects on renal volume excretion is dependent on the threshold of glucose in the nephron
📖DAPA-HF trial👉🏻NO ❌ reduction in diuretic req w/ ➕ of dapaglizflozin
✅ 15% ⤵️in BNP👉🏻LOWER effect size compared w/loops alone
