Discover and read the best of Twitter Threads about #cas9

Most recents (4)

Critical thread on "Self-Spreading #Vaccines"

Johns Hopkins Bloomberg School of Public Health, Center for #Health Security: Technologies to Address - Global Catastrophic Biological Risks, Oct 9, 2018

#biosurveillance "biological disruption" "bioterrorism events #bioengineering
"As a subset of infectious #disease emergencies, global catastrophic biological risk (#GCBR) is a special category of risk involving #biological #agents—whether naturally emerging or reemerging, deliberately created & released, or #laboratory engineered & escaped—..."

#COVID19
This "could lead to sudden, extraordinary, widespread disaster beyond the collective capability of national & int. orgs & the #privatesector to control."

"Global catastrophic biological risk", "transformational surveillance technologies"

#Foundations #CorporateConsolidation
Read 16 tweets
Intro/1 Lo Stato italiano spende ogni anno in ricerca di
base €6 MLD e in ricerca applicata €3 MLD - in tutto lo
0,5% del PIL - che è la metà di quello che spendono i
Paesi del Nord Europa #UgoAmaldi
Intro/2 Ciò ha conseguenze deleterie sulla nostra
competitività perché la ricerca pubblica è il motore
dell’innovazione tecnologica e dell’introduzione di
nuove forme di lavoro #UgoAmaldi
Intro/3 Il dopo-pandemia è il momento opportuno per
colmare il ritardo italiano nella ricerca pubblica
cominciando con l’aggiungere €1,5 MLD al bilancio 2021
della ricerca pubblica e continuando negli anni
successivi in modo da raggiungere l’1,1% del PIL nel
2026 #UgoAmaldi
Read 57 tweets
Happy to share our latest work on In Vivo Systematic Mutagenesis of a Human Enhancer @AxelVisel @diane_dickel @LenPennacchio @LBNLBioSci @BerkeleyLab

cell.com/cell/fulltext/…

Thread👇 (1/12)
A major challenge in human genomics is how to systematically assess the phenotypic impact of enhancer variants identified in human genetics studies. Mouse transgenics is a powerful tool for this purpose but has limited throughput, high cost, and so-called position effects (2/12)
To overcome these limitations, we developed a high-throughput mouse enhancer-reporter assay (enSERT) that relies on #CRISPR/#Cas9-mediated site-specific integration of a transgene into a safe harbor location of the mouse genome and supports expression in all tissues (3/12)
Read 13 tweets
Hace una semana lanzé un HILO en el que explicaba los orígenes e información básica para entender las herramientas #CRISPR. Gracias a @jm_alarcon ese HILO está recogido en esta web: threadreaderapp.com/thread/9834491… Hoy continuaré con otro en el que hablaré de las aplicaciones. Dentro HILO
Las herramientas #CRISPR nos han cambiado tanto la vida a los investigadores de ciencias de la vida que prácticamente suelo decir que pronto solamente habrá dos tipos de laboratorio: (1) los que YA están usando CRISPR en sus experimentos y (2) los que VAN a usar CRISPR. Y ya está
Lo que está ocurriendo con las #CRISPR y la edición genética de alguna manera recuerda a lo que ocurrió a finales de los años 80, cuando apareció y se instaló la técnica de amplificación del ADN #PCR (reacción de la polimerasa en cadena) que está presente hoy en todas partes.
Read 38 tweets

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