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#CausalInferenceQuestions I observe a certain effect in schizophrenia and I want to test whether it's *specifically* related to some symptoms (e.g. Delusions) and not just to the severity of the condition (e.g. as measured by positive symptoms, SAPS). 1/n
Would it make sense to model it as effect ~ Delusions + SAPS (NB model is simplified)? or better as SAPS(minusDelusions)? I'm a bit worried about the psychometric validity of the latter measure. 2/n
Also, I observe that very low scores in Delusions and SAPS show effects similar to high scores (but not medium), plausibly due to the fact that a patient with low positive symptoms needs high negative symptoms (here SANS) to be diagnosed (some sort of collider bias?).
