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@LiangGQu, Vaisnavi Thirugnanasundralingam, @damien_bolton, @UroOncMD & @lawrentschuk reviewed the role of tissue-based immunohistochemical markers for diagnosis and classification of #RCC in this 1st edition of #SIUJ!
#OpenAccess #UroSoMe

siuj.org/index.php/siuj…

1/n Image
#RCC presents various subtypes, classified according to anatomical, morphological, immunohistochemical (#IHC) & molecular features. Even after '16 reclassification, tissue biomarkers differentiate RCC subtypes & distinguish them from non-renal neoplasms or metastatic disease
2/n Image
Despite advances in #IHC staining, challenges are:
- Staining heterogeneity across and within tumors
- Variations in processing may = inconsistencies
- Revisions by @WHO & @ISUPorg = misinterpretation of older literature
- Smaller samples (biopsies) needing to be analyzed

3/n
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