Discover and read the best of Twitter Threads about #celegans

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How do brains rewire throughout life?

Our paper out in @Nature today outlines several principles of brain circuit development that we found by mapping the complete wiring of eight brains.

nature.com/articles/s4158…

#neuroscience #connectomics #brain #neurons #celegans #science
PDF available here for anyone interested in the full story: rdcu.be/cr1BK
Read 3 tweets
Our paper on flexibility in the cellular encoding of sexual state in C. elegans is out today! Great work from @TheScientistHan, @LeighWexler (former @portmanlab graduate students) and Hayley Wnuk (current graduate student). Here’s a synopsis. #celegans cell.com/current-biolog… 1/
First: this is a story about biological sex, not gender. The latter is socially and culturally influenced and is deeply tied to self-identity. Humans have this; worms don’t. 2/
Biological sex is typically seen as a static, binary characteristic. It’s not hard to see why — most species have two distinct morphs that produce different types of gametes, and this state is often set by a binary sex-determining cue (e.g., sex chromosomes). 3/
Read 25 tweets
How does the brain coordinate animal behavior across timescales?

@salazarori and I address this question in our latest from @Zimmer_Lab: “Nested neuronal dynamics orchestrate a behavioral hierarchy across timescales”

Link @NeuroCellPress:
cell.com/neuron/fulltex…

Thread 1/
@salazarori @Zimmer_Lab @NeuroCellPress In a behavioral hierarchy, as proposed by Tinbergen, long-timescale behaviors are composed of shorter-timescale ones. For example, the stickleback’s reproductive instinct (Hierarchy Level 1) includes mating and fighting (Level 2); each in turn consists of several sub-actions. 2/
@salazarori @Zimmer_Lab @NeuroCellPress Many behaviors can be described this way (e.g. recent work by @gordonberman @aexbrown @daniobrain), but are the underlying neuronal mechanisms actually hierarchical? 3/
Read 14 tweets

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