Discover and read the best of Twitter Threads about #centaurus
Most recents (17)
BREAKING🔔 The 14th paper from G2P-Japan🇯🇵 is out at Cell Host & Microbe @cellhostmicrobe. #Omicron BA.2.75 (aka #Centaurus) seems to be more contagious than BA.5 and more pathogenic than the original BA.2. Please RT. 1/16
cell.com/cell-host-micr…
cell.com/cell-host-micr…
BA.2.75, emerged in India🇮🇳, is classified as VOC-LUM (variant of concern linage under monitoring) by WHO on July 7. Here we elucidated the transmissibility, sensitivity to antiviral immunity & drugs, and intrinsic pathogenicity of BA.2.75. 2/16
who.int/activities/tra…
who.int/activities/tra…
BA.2.75 is a descendant of BA.2. However, BA.2.75 is phylogenetically different from BA.5, the currently predominant BA.2 descendant. BA.2.75 spike bears nine substitutions, but only a substitution is shared with BA.5 spike. 3/16 
#COVID19 #VariantDashboard - #UnitedStates
TOP lineages (15-DAY TRENDS):
21.4% BA.5.2.1
13.6% BA.5.2
10.9% BA.4.6
9.9% BA.5.1
3.9% BF.10
3.5% BA.5.5
3.0% BA.5.6
2.2% BF.7
2.2% BA.5.2.9
1.8% BA.5
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 10/03/22
1/n
TOP lineages (15-DAY TRENDS):
21.4% BA.5.2.1
13.6% BA.5.2
10.9% BA.4.6
9.9% BA.5.1
3.9% BF.10
3.5% BA.5.5
3.0% BA.5.6
2.2% BF.7
2.2% BA.5.2.9
1.8% BA.5
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 10/03/22
1/n
Top circulating lineages (#15DayTrends)
81.7% BA.5*
10.9% BA.4.6*
2.2% BF.7*
1.5% BA.2.75*
1.4% BA.4*
1.4% BQ.1*
0.5% BQ.1.1*
0.2% BA.2.3.30*
0.02% XBB*
2/n
81.7% BA.5*
10.9% BA.4.6*
2.2% BF.7*
1.5% BA.2.75*
1.4% BA.4*
1.4% BQ.1*
0.5% BQ.1.1*
0.2% BA.2.3.30*
0.02% XBB*
2/n
Diese #Herbstwelle wird #keine klassische #Varianten-#Welle, wie die 6 Wellen zuvor (2xD614G, B.1.1.7, Delta, BA.1, BA.2, BA.4/5) sondern wir sehen alle möglichen BA.2 Sublinien, die alle die gleichen Mutationen aufweisen (493 Reversion An Position 346 444 452, 460, 486 /1
Es entsteht eine Situation, die die Wissenschaftler so zuvor bei SARS-CoV2 vorher noch nie beobachtet hatten: konvergente Evolution überall weltweit, immer die gleichen Mutationen = koplett unübersichtliche Lage. "Something #big ist happening with SC2, /2
Absolute Leseempfehlung für diesen Thread von @shay_fleishon ⤵️wenn jemand da näher einsteigen will. Fakt ist dass dies eine für die Pandemie völlig #neue #Situation : #Überall ploppen #Subvarianten und Second-Generation Varianten von BA.2 und BA.5 auf,
/3
/3
#COVID19 #VariantDashboard - #UnitedStates
TOP lineages (15-DAY TRENDS):
23.2% BA.5.2.1
13.5% BA.5.2
10.6% BA.5.1
10.0% BA.4.6
4.0% BF.10
3.3% BA.5.5
2.8% BA.5.6
2.4% BA.5.2.9
2.2% BF.7
2.0% BA.5
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 10/02/22
1/n
TOP lineages (15-DAY TRENDS):
23.2% BA.5.2.1
13.5% BA.5.2
10.6% BA.5.1
10.0% BA.4.6
4.0% BF.10
3.3% BA.5.5
2.8% BA.5.6
2.4% BA.5.2.9
2.2% BF.7
2.0% BA.5
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 10/02/22
1/n
Top circulating lineages (#15DayTrends)
83.7%BA.5*
10% BA.4.6*
2.2%BF.7*
1.5%BA.4*
1.2%BA.2.75*
0.5%BQ.1*
0.3%BA.2.3.30*
0.4%BQ.1.1*
2/n
83.7%BA.5*
10% BA.4.6*
2.2%BF.7*
1.5%BA.4*
1.2%BA.2.75*
0.5%BQ.1*
0.3%BA.2.3.30*
0.4%BQ.1.1*
2/n
#COVID19 #VariantDashboard - #UnitedStates
TOP lineages (15-DAY TRENDS):
22.18% BA.5.2.1
12.64% BA.5.2
10.88% BA.4.6
10.02% BA.5.1
4.19% BA.5
3.63% BA.5.5
3.23% BA.5.6
3.04% BF.10
2.32% BA.5.2.9
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/27/22
1/n
TOP lineages (15-DAY TRENDS):
22.18% BA.5.2.1
12.64% BA.5.2
10.88% BA.4.6
10.02% BA.5.1
4.19% BA.5
3.63% BA.5.5
3.23% BA.5.6
3.04% BF.10
2.32% BA.5.2.9
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/27/22
1/n
Top circulating lineages:
82.4% BA.5*
10.9% BA.4.6*
2.7% BA.4*
1.4% BF.7*
0.8% BA.2.75*
0.7% BQ.1* 👀
0.2% BQ.1.1*👀
0.3% BA.2.75.2*
0.05% BA.2.3.20*
0.02% BJ.1*
2/n
82.4% BA.5*
10.9% BA.4.6*
2.7% BA.4*
1.4% BF.7*
0.8% BA.2.75*
0.7% BQ.1* 👀
0.2% BQ.1.1*👀
0.3% BA.2.75.2*
0.05% BA.2.3.20*
0.02% BJ.1*
2/n
#COVID19 #VariantDashboard - #UnitedStates
TOP lineages (15-DAY TRENDS):
22.33% BA.5.2.1
12.87% BA.5.2
10.53% BA.4.6
10.33% BA.5.1
3.71% BA.5
3.69% BA.5.5
3.43% BA.5.6
3.11% BF.10
2.67% BA.5.2.9
1.59% BF.5
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/26/22
1/n
TOP lineages (15-DAY TRENDS):
22.33% BA.5.2.1
12.87% BA.5.2
10.53% BA.4.6
10.33% BA.5.1
3.71% BA.5
3.69% BA.5.5
3.43% BA.5.6
3.11% BF.10
2.67% BA.5.2.9
1.59% BF.5
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/26/22
1/n
Top circulating lineages:
82.62% BA.5*
10.53% BA.4.6*
2.68% BA.4*
1.45% BF.7*
0.94% BA.2.75*
0.62% BQ.1* 👀
0.20% BQ.1.1*👀
0.25% BA.2.75.2*
0.05% BA.2.3.20*
0.03% BJ.1*
2/n
82.62% BA.5*
10.53% BA.4.6*
2.68% BA.4*
1.45% BF.7*
0.94% BA.2.75*
0.62% BQ.1* 👀
0.20% BQ.1.1*👀
0.25% BA.2.75.2*
0.05% BA.2.3.20*
0.03% BJ.1*
2/n
#COVID19 #VariantDashboard - #UnitedStates
TOP lineages (15-DAY TRENDS):
21.86% BA.5.2.1
12.79% BA.5.2
11.39% BA.4.6⬆️
10.89% BA.5.1
3.83% BA.5
3.55% BA.5.5
3.13% BA.5.6
3.02% BF.10
2.55% BA.5.2.9
1.59% BF.5
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/25/22
1/n
TOP lineages (15-DAY TRENDS):
21.86% BA.5.2.1
12.79% BA.5.2
11.39% BA.4.6⬆️
10.89% BA.5.1
3.83% BA.5
3.55% BA.5.5
3.13% BA.5.6
3.02% BF.10
2.55% BA.5.2.9
1.59% BF.5
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/25/22
1/n
Top circulating lineages:
82.23% BA.5*
11.39% BA.4.6*
2.35% BA.4*
1.37% BF.7*
1.04% BA.2.75*
0.67% BQ.1* 👀
0.21% BQ.1.1*👀
0.18% BA.2.75.2*
0.05% BA.2.3.20*
0.05% BJ.1*
2/n
82.23% BA.5*
11.39% BA.4.6*
2.35% BA.4*
1.37% BF.7*
1.04% BA.2.75*
0.67% BQ.1* 👀
0.21% BQ.1.1*👀
0.18% BA.2.75.2*
0.05% BA.2.3.20*
0.05% BJ.1*
2/n
BA.5* group of lineages have outcompeted all other circulating lineages in the USA.
@CDCgov updated variant proportions estimates on 9/23/2022
3/n
@CDCgov updated variant proportions estimates on 9/23/2022
3/n
BA.2.75.2 (subvariant of #Centaurus) is one to watch. Early data suggests Omicron BA.2.75.2 exhibits more extreme antibody escape than any variant to date. It’s too early to know whether this will result in a wave
Further explanation here. Neutralizing antibody levels for vaccinated & (overwhelmingly) infected serum is >5-fold lower than BA.5 & nearly 4-fold lower than BA.4.6
You can catch up on some of the history of BA.2.75.2 here. This variant has been growing quickly in India.
#COVID19 #VariantDashboard - #UnitedStates
TOP lineages (15-DAY TRENDS):
31.05% BA.5.2.1
17.11% BA.5.2
12.23% BA.5.1
9.03% BA.4.6
5.08% BA.5.5
5.03% BA.5.6
4.01% BA.5
2.19% BA.4.1
2.01% BF.5
1.50% BE.1
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/13/22
1/n
TOP lineages (15-DAY TRENDS):
31.05% BA.5.2.1
17.11% BA.5.2
12.23% BA.5.1
9.03% BA.4.6
5.08% BA.5.5
5.03% BA.5.6
4.01% BA.5
2.19% BA.4.1
2.01% BF.5
1.50% BE.1
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/13/22
1/n
Top circulating lineages:
84.80% BA.5*
12.56% BA.4* [of which 9.03% BA.4.6]
0.94% BA.2.75* 👀
1.7% Others
2/n
84.80% BA.5*
12.56% BA.4* [of which 9.03% BA.4.6]
0.94% BA.2.75* 👀
1.7% Others
2/n
Now the spotlight is on #Oregon, #NewHampshire, #Maine & #Maryland!
Week-over-week trend in new confirmed SARSCoV2 positive cases is >60%
Source: charts.medriva.com/us/
3/n
Week-over-week trend in new confirmed SARSCoV2 positive cases is >60%
Source: charts.medriva.com/us/
3/n
#COVID19 #VariantDashboard - #UnitedStates
TOP lineages (15-DAY TRENDS):
30.13% BA.5.2.1
17.45% BA.5.2
12.90% BA.5.1
9.42% BA.4.6👀
5.11% BA.5.5
4.93% BA.5.6
3.95% BA.5
2.24% BF.5
2.04% BA.4.1
1.56% BE.1.1
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/12/22
1/n
TOP lineages (15-DAY TRENDS):
30.13% BA.5.2.1
17.45% BA.5.2
12.90% BA.5.1
9.42% BA.4.6👀
5.11% BA.5.5
4.93% BA.5.6
3.95% BA.5
2.24% BF.5
2.04% BA.4.1
1.56% BE.1.1
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/12/22
1/n
Top circulating lineages:
85.36% BA.5*
12.74% BA.4* [of which 9.42% BA.4.6]
1.11% BA.2.75* 👀
0.79% Others
2/n
85.36% BA.5*
12.74% BA.4* [of which 9.42% BA.4.6]
1.11% BA.2.75* 👀
0.79% Others
2/n
Now the spotlight is on #Oregon, #WestVirginia and #Florida!
Week-over-week trend in new confirmed SARSCoV2 positive cases is >50%
Source: charts.medriva.com/us/
3/n
Week-over-week trend in new confirmed SARSCoV2 positive cases is >50%
Source: charts.medriva.com/us/
3/n
#COVID19 #VariantDashboard - #UnitedStates
TOP lineages (15-DAY TRENDS):
28.93% BA.5.2.1
17.78% BA.5.2
13.11% BA.5.1
9.96% BA.4.6👀
5.23% BA.5.5
4.56% BA.5.6
4.34% BA.5
2.26% BF.5
2.09% BA.4.1
1.58% BA.5.1.1
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/11/22
1/n
TOP lineages (15-DAY TRENDS):
28.93% BA.5.2.1
17.78% BA.5.2
13.11% BA.5.1
9.96% BA.4.6👀
5.23% BA.5.5
4.56% BA.5.6
4.34% BA.5
2.26% BF.5
2.09% BA.4.1
1.58% BA.5.1.1
Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/11/22
1/n
Top circulating lineages:
84.59% BA.5*
13.37% BA.4* [of which 9.96% BA.4.6]
0.97% BA.2.75*
1.07% Others
2/n
84.59% BA.5*
13.37% BA.4* [of which 9.96% BA.4.6]
0.97% BA.2.75*
1.07% Others
2/n
Now the spotlight is on #Oregon!
Week-over-week trend in new confirmed SARSCoV2 positive cases is ~24%
Source: charts.medriva.com/us/
3/n
Week-over-week trend in new confirmed SARSCoV2 positive cases is ~24%
Source: charts.medriva.com/us/
3/n
1\n
WEEKBERICHT 33
CORONA #Oversterfte
Wk 33 19 aug 2022
CBS: 439† (68%)
AB: 764† (30%)
Pandemie t/m week 31
AB: 84.500† RIP
Bron: @falsel_net @AlleBurgers (AB) Human Mortality Database
Fig 1 ht @falsel_net
WEEKBERICHT 33
CORONA #Oversterfte
Wk 33 19 aug 2022
CBS: 439† (68%)
AB: 764† (30%)
Pandemie t/m week 31
AB: 84.500† RIP
Bron: @falsel_net @AlleBurgers (AB) Human Mortality Database
Fig 1 ht @falsel_net
2\n
2. PROGNOSE Oversterfte
De infectieverspreiding is sterk gedaald tot ca 2.000 (minstens 5-10x onderschat: met ca 16.000 nog altijd zeer hoog, ondanks de vakanties en het goede weer, en nog wel iets dalend (ca 2% op weekbasis)
Bron: RIVM
Fig ht @roelgrif
2. PROGNOSE Oversterfte
De infectieverspreiding is sterk gedaald tot ca 2.000 (minstens 5-10x onderschat: met ca 16.000 nog altijd zeer hoog, ondanks de vakanties en het goede weer, en nog wel iets dalend (ca 2% op weekbasis)
Bron: RIVM
Fig ht @roelgrif
3\n
De exponentiële daling wordt ook bevestigd in de daling van de rioolwaarden. Naar verwachting zal de daling richting stabilisatie gaan wanneer de schoolvakanties beginnen, en vervolgens al vroeg in het seizoen weer stijgen.
Fig ht @roelgrif
De exponentiële daling wordt ook bevestigd in de daling van de rioolwaarden. Naar verwachting zal de daling richting stabilisatie gaan wanneer de schoolvakanties beginnen, en vervolgens al vroeg in het seizoen weer stijgen.
Fig ht @roelgrif
„Potenzielles Risiko von BA.2.75 für die globale Gesundheit größer als das von BA.5“
BA.2.75 ist ein BA.2-Abkömmling, unterscheidet sich aber phylogenetisch von BA.5, dem derzeit vorherrschenden BA.2-Abkömmling. Diese Studie zeigt, dass die…
#COVID19 #Corona #LongCovid
BA.2.75 ist ein BA.2-Abkömmling, unterscheidet sich aber phylogenetisch von BA.5, dem derzeit vorherrschenden BA.2-Abkömmling. Diese Studie zeigt, dass die…
#COVID19 #Corona #LongCovid
…effektive Reproduktionszahl von BA.2.75 größer ist als die von BA.5.
Der BA.2.75-Spike wies eine deutlich höhere Affinität zu menschlichem ACE2 auf als die BA.2- und BA.5-Spikes. Die Fusogenität, die Wachstumseffizienz in menschlichen Alveolarepithelzellen und die…
Der BA.2.75-Spike wies eine deutlich höhere Affinität zu menschlichem ACE2 auf als die BA.2- und BA.5-Spikes. Die Fusogenität, die Wachstumseffizienz in menschlichen Alveolarepithelzellen und die…
…intrinsische Pathogenität von BA.2.75 in Hamstern waren mit denen von BA.5 vergleichbar, aber größer als die von BA.2. Diese multiskaligen Untersuchungen deuten darauf hin, dass BA.2.75 unabhängig von BA.5 virologische Eigenschaften erworben hat, und dass das potenzielle…
BREAKING🔔 The 13th preprint from G2P-Japan🇯🇵 is out @biorxivpreprint. #Omicron BA.2.75 (aka #Centaurus) seems to be more contagious than BA.5 and more pathogenic than the original BA.2. Please RT. 1/7
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
BA.2.75, emerged in India🇮🇳, is classified as VOC-LUM (variant of concern linage under monitoring) by WHO on July 7. Here we elucidated the effective reproduction number, sensitivity to antiviral immunity & drugs and intrinsic pathogenicity of BA.2.75. 2/7
who.int/activities/tra…
who.int/activities/tra…
Both BA.2.75 and BA.5 are descendants of BA.2. However, BA.2.75 is phylogenetically different from BA.5, the currently predominant BA.2 descendant. BA.2.75 spike bears nine substitutions, but only one substitution (R493Q) is shared with BA.5 spike. 3/7
🎉CoVariants.org Update!🎉
22D (BA.2.75) is now available on CoVariants! It's visible as part of Per Country & Per Variant plots, on the shared mutation page - and of course, has a page of its own!
1/8
#BA275 #centaurus
covariants.org/variants/22D.O…
22D (BA.2.75) is now available on CoVariants! It's visible as part of Per Country & Per Variant plots, on the shared mutation page - and of course, has a page of its own!
1/8
#BA275 #centaurus
covariants.org/variants/22D.O…
This is in line with the recent addition of 22D (BA.2.75) as a @nextstrain clade - read more on that below! 👇🏻
2/8
2/8
On the 22D page, you can read about some initial 22D / BA.2.75 work on things like immune-evasion, see a list of defining mutations, a plot of the variant growth, link to Aquaria protein viz, & see a list of other mutations present in the variant.
3/8
covariants.org/variants/22D.O…
3/8
covariants.org/variants/22D.O…
Reminder that the *entire* point of Greek letter is precisely *because* anyone _can_ name a variant. That's how we end up with potentially inaccurate & discriminatory names.
If we/@WHO don't provide useful names for use, alternative names will start to appear.
#CentaurusStrain
If we/@WHO don't provide useful names for use, alternative names will start to appear.
#CentaurusStrain
We got lucky in a way with the 'first level' BA's (BA.1-BA.5) because they're simple enough for everyone to use & repeat.
But Pango lineages by nature can sometimes be more unwieldy: like BA.2.75 (which isn't even so bad). People start using shorthand!
But Pango lineages by nature can sometimes be more unwieldy: like BA.2.75 (which isn't even so bad). People start using shorthand!
Yes, we can ask people *not* to make up their own names.
But all we can do is ask.
If we don't address *why* people are coming up with alternative names - because they need an easier, recognisable handle - we run the risk they'll do it anyway. 💁🏻♀️
But all we can do is ask.
If we don't address *why* people are coming up with alternative names - because they need an easier, recognisable handle - we run the risk they'll do it anyway. 💁🏻♀️
USA: BA2 Anteil hat sich verdoppelt
Neue @CDCgov Daten zeigen, dass sich #BA2 von 11,6 % letzte Woche auf 23,1 % verdoppelt hat. Nach unserem Varianten-Modell wird BA2 die Dominanz in den #USA in 2 1/2 Wochen erreichen covid.cdc.gov/covid-data-tra…
Neue @CDCgov Daten zeigen, dass sich #BA2 von 11,6 % letzte Woche auf 23,1 % verdoppelt hat. Nach unserem Varianten-Modell wird BA2 die Dominanz in den #USA in 2 1/2 Wochen erreichen covid.cdc.gov/covid-data-tra…
#USA: BA2121 Anteil steigt über 17% Marke
Follower kennen bereits die Bedeutung der 17% Marke im AITask Varianten-Modell: #BA2121 ist in den #USA auf dem Weg zur Dominanz - trotz #BA2 - und das in neuer Rekordzeit🔴🚑🏥
Follower kennen bereits die Bedeutung der 17% Marke im AITask Varianten-Modell: #BA2121 ist in den #USA auf dem Weg zur Dominanz - trotz #BA2 - und das in neuer Rekordzeit🔴🚑🏥
#USA: Variante BA5 wird dominat
BA5 steht in den USA kurz vor der Dominanz. Wie zuvor modelliert wird #BA5 die Variante #BA2121 ablösen. Die Grafik enthält den Trend der #Modellierung aus 05/2022 und die neusten #Varianten-Daten aus den USA:🦠🌊🚑🏥
covid.cdc.gov/covid-data-tra…
BA5 steht in den USA kurz vor der Dominanz. Wie zuvor modelliert wird #BA5 die Variante #BA2121 ablösen. Die Grafik enthält den Trend der #Modellierung aus 05/2022 und die neusten #Varianten-Daten aus den USA:🦠🌊🚑🏥
covid.cdc.gov/covid-data-tra…
