Discover and read the best of Twitter Threads about #cfs_unparch
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Examples from our Protein Common Assembly Db now on @biorxiv_bioinfo with @QifangXu. Viable assemblies for all Xray structures (EPPIC, @josemduarte), clustered w/ cryoEM, NMR assemblies by Pfam architectures + stoichiometry+ symmetry + interfaces. @buildmodels @PDBeurope @pdbj_en 
We count "Crystal forms (CFs)" - unique crystal unit cells or cryo-EM or NMR experiments for each cluster, and number of uniprot sequences across each cluster. More experimental data --> more support for relevance of biological assembly. Also #PDB's bioassemblies, PISA, EPPIC.
PCNA example from 1st tweet. Largest cluster (#8) of Pfam arch (PCNA_N)_(PCNA_C) has 28 crystal forms (CFs) out of 36 CFs for this Pfam architecture in whole in PDB (78%). 19 UNPs of 23 in whole PDB (83%). 55 entries of 64 in whole PDB (86%).
dunbrack2.fccc.edu/ProtCAD/Result…
dunbrack2.fccc.edu/ProtCAD/Result…
