Discover and read the best of Twitter Threads about #cgas
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(1/n) A brief #tweetorial highlighting the key aspects of our recent paper in #Cancer Discovery @CD_AACR on how cancers with #Chromosomal_Instability evade immune surveillance prompting #metastasis #ScienceTwitter cancerdiscovery.aacrjournals.org/content/early/…
We’ve previously shown that CIN can drive #metastasis through the generation of chronic #inflammation arising from persistent activation of #cGAS #STING signaling. However it wasn’t clear how cells eschewed the immune stimulating effect of this pathway. nature.com/articles/natur…
To address this, we compared isogenic cells with high vs. low levels of CIN and found that cells with high levels of CIN upregulated #ENPP1 an extracellular enzyme shown by @lingyinli1 and Tim Mitchison to hydrolyze #cGAMP
cGAS-STING work continues to boggle the mind - flurry of new papers in the last two weeks branching the field in new directions. I’ll try for quick (not really) takes… #cGAS #microbiology #Immunology #Inflammation @nature @biorxivpreprint @NatureMicrobiol @CellReports
Paper 1: @aaronwhiteley et al writing in @nature - nature.com/articles/s4158…. cGAS-like nucleotidyltransferases in bacteria (CD-NTases) synthesize a wide range of cyclic dinucleotides (CDNs) - and more, including trinucleotides (CTNs?)!
Different CDNs and CTNs activate different host sensors - for example, many that don’t activate STING instead activate RECON. Dozens of CD-NTases are shown to synthesize a wide range of products, including CTNs - which can also activate RECON.
