Discover and read the best of Twitter Threads about #cgas

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(1/n) A brief #tweetorial highlighting the key aspects of our recent paper in #Cancer Discovery ⁦@CD_AACR⁩ on how cancers with #Chromosomal_Instability evade immune surveillance prompting #metastasis #ScienceTwitter…
We’ve previously shown that CIN can drive #metastasis through the generation of chronic #inflammation arising from persistent activation of #cGAS #STING signaling. However it wasn’t clear how cells eschewed the immune stimulating effect of this pathway.…
To address this, we compared isogenic cells with high vs. low levels of CIN and found that cells with high levels of CIN upregulated #ENPP1 an extracellular enzyme shown by @lingyinli1 and Tim Mitchison to hydrolyze #cGAMP
Read 16 tweets
cGAS-STING work continues to boggle the mind - flurry of new papers in the last two weeks branching the field in new directions. I’ll try for quick (not really) takes… #cGAS #microbiology #Immunology #Inflammation @nature @biorxivpreprint @NatureMicrobiol @CellReports
Paper 1: @aaronwhiteley et al writing in @nature -…. cGAS-like nucleotidyltransferases in bacteria (CD-NTases) synthesize a wide range of cyclic dinucleotides (CDNs) - and more, including trinucleotides (CTNs?)!
Different CDNs and CTNs activate different host sensors - for example, many that don’t activate STING instead activate RECON. Dozens of CD-NTases are shown to synthesize a wide range of products, including CTNs - which can also activate RECON.
Read 23 tweets

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