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This is indeed a thoughtful take on #challengetrials for coronavirus vaccine development. I have a few thoughts too.
First, appreciate that Nir and @mlipsitch posted this ASAP for the world to see as a preprint. Marc, is it under review?
One big pt seems to be exactly (or approximately) how much time would be cut off vaccine approval if we take this approach. OTOH, even short time off could be impt if we have small # of people in challenge trial (most of whom will be OK) + more people dying each day we wait.
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