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Proud to announce that my first first-author paper is online! We (@Taylor_Lab_Cam, @PhilHolliger and our co-workers) demonstrate how a novel engineered polymerase unlocks efficient synthesis and evolution of therapeutic 2'-modified nucleic acids.
nature.com/articles/s4155…
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nature.com/articles/s4155…
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Almost twenty nucleic acid therapeutics have been approved for use in the clinic. Antisense oligos are synthesised by solid-phase synthesis, which is efficient but costly, limited to short oligomers and hard to scale up to large numbers of sequence or chemistry variants. (2/n) 
Discovery might be accelerated by tools for the rapid synthesis of many variants: polymerases. Also, for antisense therapeutics (obvious sequence), rational design is feasible, but for therapeutic modalities like aptamers, polymerases enabling in vitro evolution are needed. (3/n)
