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Wondering whether axonal input *drives* fMRI-based functional connectivity? Us too!

Here is what we found using #chemogenetic deconstruction of rsfMRI in the mouse🐁🐭

➡️Cortical silencing results in paradoxical fMRI overconnectivity

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Computational and empirical evidence suggest that structural and functional connectivity are robustly related

➡️ this recent review from @richardfbetzel @misicbata summarizes it all

⚠️A key prediction of structurally based models of fMRI coupling is that *inactivation* of a brain node would result in reduced rsfMRI connectivity with its targets⚠️

But is that really the case?

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