Discover and read the best of Twitter Threads about #chemokines

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Diese neue Studie untersucht, wie selbst eine milde #COVID19-Erkrankung das Gehirn beeinflussen kann. Es gibt deutliche Parallelen zwischen der zellulären Dysregulation, die nach einer Chemotherapie und einer leichten #COVID Infektion auftreten kann.

#coronavirus
#LongCovid Image
Das Verständnis der neurobiologischen Grundlagen von #LongCOVID wird die Grundlage für therapeutische Strategien zur Bewältigung dieser neurologischen Gesundheitskrise bilden

Zusammengefasst unterstreichen die Ergebnisse dieser Studie, dass die Immunantwort auch auf leichte…
#COVID19 Infektionen außerhalb des Gehirns eine Neuroinflammation und folglich eine Dysregulation der Nervenzellen verursachen kann, die die Gehirnfunktion beeinträchtigen kann. Image
Read 8 tweets
The final version of our study seeking to understand how even mild respiratory COVID can affect the brain is now published. Sharing an updated thread… 1/

Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation cell.com/cell/fulltext/…
COVID survivors frequently suffer from lasting cognitive symptoms. Noting the clinical similarities between “chemo-fog” and “COVID-fog”, we asked whether there are also neurobiological similarities, in collaboration with Akiko Iwasaki’s @VirusesImmunity lab @YaleMed. 2/
How might even mild respiratory #COVID infection affect the brain? Using a mouse model of mild SARS-CoV-2 infection limited to the respiratory system, we found elevation of CNS cytokines/chemokines and white matter-specific microglial reactivity. 3/ Image
Read 17 tweets
#LongCOVID frequently includes cognitive symptoms. Noting the clinical similarities between “chemo-fog” and “COVID-fog”, we asked whether there are also neurobiological similarities, in collaboration with Akiko Iwasaki’s @VirusesImmunity lab @YaleMed. 🧵 biorxiv.org/content/10.110…
How might even mild respiratory #COVID-19 infection affect the brain? Using a mouse model of mild SARS-CoV-2 infection limited to the respiratory system, we found elevation of CNS cytokines/chemokines and white matter-specific microglial reactivity.
One of these #chemokines - known to be associated with cognitive impairment – is also elevated in people suffering from #LongCOVID with cognitive symptoms compared to those with LongCOVID and no cognitive symptoms. Collaboration with @PutrinoLab @MountSinaiNYC
Read 8 tweets

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