Discover and read the best of Twitter Threads about #chromatin

Most recents (5)

Congrats to Hayley Zullow of @kadochlab @HarvardMITmdphd @BBS_Harvard programs and our team, including @akshaysci, @JunQiLab, @ar_davino, and many others, on this exciting new study out today in @MolecularCell @CellPressNews ! Tweetorial below: (1/7) cell.com/molecular-cell…
Here, we explore the impact of the #fusion oncoprotein hallmark to #myxoidliposarcoma, FUS-DDIT3, and its impact on #BAF #SWISNF complex-mediated #chromatin remodeling activities genome wide. (2/7)
We previously showed that fusions such as SS18-SSX and EWS-FLI1, in #synovialsarcoma and #Ewingsarcoma, respectively, interact with BAF complexes and direct their genomic occupancy in a cancer-specific, gain-of-function manner. (3/7)
Read 7 tweets
Really chuffed to share our latest work from Sanjana Lab out in @nature today (nature.com/articles/s4158…).

We tested >12,000 genes to find positive regulators of T cell proliferation to be used for next-gen #immunotherapies.

A thread...
(2/28) T cell therapies have shown the potential to cure patients from #cancer – but even in B cell cancers, relapses outnumber cures… One of the problems is limited T cell persistence. #celltherapy #CARTcell
(3/28) We wanted to find new genes (including genes never expressed in T cells) that could improve T cell persistence. Now, the question was: should we use #crispr activation or directly deliver target genes on a #lentivirus?
Read 30 tweets
Please enjoy our new #preprint, "High-throughput discovery and characterization of human transcriptional effectors"! 😀

We tested thousands of protein domains and mutants for the ability to repress/activate #GeneExpression and ID effectors in 600 proteins
biorxiv.org/content/10.110…
For many human #TranscriptionFactors & #chromatin regulators, we know more about *where* they bind than *how* they regulate expression

To find effector domains in an unbiased way, we tested a library of the majority of nuclear protein domains with our new method, HT-recruit Image
We find hundreds of human #repressor domains, including several domains of unknown function Image
Read 13 tweets
Proud to share our new paper!! We explored recent evidence on #epigenetics #transposons and #population #genetics to look beyond the two-speed genome evolution model!! @OggenfussUrsula @danielcroll @MFSeidl sciencedirect.com/science/articl…
Genomic compartments specifically benefit plant pathogen lifestyle? Well... genomic compartments occur all across the tree of life @OggenfussUrsula @MFSeidl @danielcroll Image
Then, they are a consequence of #transposon insertions and accumulation? Or a consequence of #chromatin organization? Probably both! @OggenfussUrsula @danielcroll @MFSeidl Image
Read 3 tweets
1/ Excited to share work led by @varshney_arushi genetics.org/content/211/2/… @GeneticsGSA, we compared gene regulatory annotations defined using diverse #epigenomic data across 4 cell types to measure cell specificities and #genetics of #geneRegulation
2/ We observed that stretch and super #enhancers are more cell type-specific whereas HOT regions and broad domains comprise more ubiquitous promoter states
3/ #eQTL in stretch enhancers have significantly smaller effect sizes compared to those in HOT regions. This suggests regulatory buffering where the expression of cell-identity genes is more tightly controlled
Read 6 tweets

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