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Delighted to see our work on post-prandial insulin resistance published nature.com/articles/s4158… Its the result of a great collaboration with, among others, #ClaudiaLangenberg @omicscience, @DPhaz @klmohlke, #EleanorWheeler and #NickWareham
The first author is Alice @ AC_Williamson, a terrific PhD student with Claudia and me. In 2000 with @satya Dash009 , #David Savage we described a family where a mutation in a Rab-GAP for GLUT4, TBC1D4, impaired GLUT4 translocation in response to insulin in muscle and fat/2.
The mutation co-segregated with extremely high post-meal insulin levels. Clearly, the normal pancreas was somehow sensing the abnormally slow rate of disappearance of glucose into muscle and fat tissues, where both GLUT4 and TBC1D4 are normally expressed/3
