Discover and read the best of Twitter Threads about #clecliniccancer

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Radiation to the prostate for metastatic prostate cancer is now endorsed by NCCN 2019. This topic can be a bit confusing, so here is a tweetorial for residents & community practice #radonc docs (including my #CleClinicCancer colleagues taking oral boards soon). #pcsm 1/21
I recently pieced together some key points on primary prostate RT for M1 for a resident teaching session, which I thought I’d share here. Apologies in advance if any typos or errors in this thread. 2/21
First, some definitions. mCSPC = metastatic castrate sensitive prostate ca. MDT = metastasis directed therapy (surgery or SBRT to all sites). Oligomets = 1-3 or 1-5 mets. 3/21
Read 23 tweets
(1/n) Excited that final version of work led by @D4N__ studying evolutionary repeatability and collateral sensitivity is out. #mathevo #clecliniccancer nature.com/articles/s4146… @CCLRI @NatureComms @CWRUSOM
(2/n) This collab between @CompSciOxford @CCLRI @CWRUSOM & @MoffittPSOC is an extension of @D4N__ ‘s initial theory paper that proposed ‘steering evolution’ as a method of extending the use of existing drugs to control infection. #AntibioticResistance journals.plos.org/ploscompbiol/a…
(3/n) using the fitness landscape metaphor, we reasoned that instances of collateral sensitivity need not be repeatable, as evolutionary branch points could lead to multiple peaks - which could have different sensitivity profiles.
Read 11 tweets

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