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Delighted to share our latest paper in #JCO, in which we suggest an MRD growth model of CLL, including new data from the CLL14 study (Ven-Obi vs Clb-Obi). #leusm #GCLLSG @ASCO_pubs
bit.ly/2ZyAVEZ
Some results in a quick 🧵 1/n
bit.ly/2ZyAVEZ
Some results in a quick 🧵 1/n
1.) We used NGS-based MRD quantification of >2,000 PB samples to devise a non-linear mixed effects model for outlining MRD growth after tx. There was wide heterogeneity in MRD growth trajectories that was dependent on various clinical, serological and genetic characteristics. 
2.) Notably, one of the most important determinant of MRD growth was actually the choice of therapy: Patients who received Ven-Obi had a signif longer MRD doubling time and time to MRD conversion than pts who received chemo with Clb-Obi.
