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This week some of my discussions have centred on #ClusterTrials. Cluster trials involve the randomisation of intact units (wards, hospitals, GP practices etc) rather than individuals. They have a number of key elements that must be accounted for 1/11
#MethodologyMonday
#MethodologyMonday
There are very good reasons for cluster/group randomisation eg when evaluating interventions like clinical guidelines or educational interventions which apply at practice/hospital level; or when there is potential of contamination of the intervention across trial groups 2/11
However, cluster randomisation has some major impacts for design & analysis primarily because observations within a cluster are not independent (outcomes are likely to be more similar within a cluster) 3/11
