Discover and read the best of Twitter Threads about #connectome
Most recents (3)
What are the design principles of neural connectomes?
We show that a small # of biophysical features shape the structure and function of connecotmes in zebrafish, mice, & c. elegans.
lead by @_adam_haber, w/@RainerFriedri12 & @AdrianAWanner
doi.org/10.1101/2023.0…
1/n
We show that a small # of biophysical features shape the structure and function of connecotmes in zebrafish, mice, & c. elegans.
lead by @_adam_haber, w/@RainerFriedri12 & @AdrianAWanner
doi.org/10.1101/2023.0…
1/n
The map of synaptic connectivity among neurons shapes the computations that neural circuits perform. Identifying the design principles of connectomes is fundamental for understanding brain development and architecture, neural computations, learning, and behavior... 2/n
We therefore learned probabilistic generative models for connectomes of the olfactory bulb of zebrafish, the mouse visual cortex, and of C. elegans .. 3/n
How useful is a connectome? We show that you can predict quite a bit about the neural activity of a circuit from just measurements of its connectivity. Led by star graduate student @lappalainenjk, collaboration with @jakhmack. #connectome biorxiv.org/cgi/content/sh… 1/n
How much does a connectome tell you about neural computations? This has been hotly debated (e.g. @SebastianSeung @TonyMovshon
scientificamerican.com/article/c-eleg… )?
Tricky because you don’t know much about single neuron + synapse dynamics, neuromodulation, ... ! 2/n
scientificamerican.com/article/c-eleg… )?
Tricky because you don’t know much about single neuron + synapse dynamics, neuromodulation, ... ! 2/n
Here we show that you can predict neural activity from neural connectivity measurements-- provided you can guess what the network is supposed to do. With the weight matrix essentially given by the connectome, we use #taskoptimization to estimate single neuron parameters. 3/n
1/🧵 Tweetorial on our new paper, “Dump the Dimorphism: Comprehensive synthesis of brain studies finds few male-female differences beyond size.” (sciencedirect.com/science/articl…). It's big (43K words, 616 refs) so I'll cut to the chase.
2/ Surveyed hundreds of human #sexdifference studies since the dawn of MRI (structural & functional). Enough to answer the perennial question “How different are men and women’s brains?”
3/ And the answer is . . .“Hardly at all!”
