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Really impressive talk on noncoding #constraint in #gnomAD genomes from Siwei Chen (@konradjk's lab).
#ASHG21
#ASHG21
Chen: Calculated constraint on 1kb windows using Z scores.
How do known non-coding elements (like enhancers) look when viewed through the lens on constraint?
#ASHG21
How do known non-coding elements (like enhancers) look when viewed through the lens on constraint?
#ASHG21
Chen: When looking at largest constraint Z-scores (top Z-score was 4 on the figures)
- Super enhancers ~3x enriched
- ENCODE cCRE enhancers ~2.25x enriched
- FANTOM enhancers ~1.75x enriched
#ASHG21
- Super enhancers ~3x enriched
- ENCODE cCRE enhancers ~2.25x enriched
- FANTOM enhancers ~1.75x enriched
#ASHG21
