Discover and read the best of Twitter Threads about #costvr
Most recents (7)
1) Explain this: The life-saving leukemia drug imatinib costs only $480 per year at @costplusdrugs @mcuban
Instead of the $100,000+ retail price. How? Why?
thelancet.com/journals/lanha… #MedTwitter
Instead of the $100,000+ retail price. How? Why?
thelancet.com/journals/lanha… #MedTwitter
2) How is this even possible?
Important article by @DrHKantarjian et al @MDAndersonNews @TheLancetHaem explains the how and why. thelancet.com/journals/lanha… #CostVR
Important article by @DrHKantarjian et al @MDAndersonNews @TheLancetHaem explains the how and why. thelancet.com/journals/lanha… #CostVR
3) Imatinib is a life saving drug for chronic myeloid leukemia. The poster child for successful targeted cancer treatment. It was introduced in 2001 at $32000 per year.
Price rose to >$100,000 by 2012. Lesson 1: Price of old drugs in USA increase markedly for no apparent reason
Price rose to >$100,000 by 2012. Lesson 1: Price of old drugs in USA increase markedly for no apparent reason
Lenalidomide cost per month
$100 in India
$1000 in Europe
$18,000 in USA
No wonder lenalidomide is the #2 drug Medicare spends the most money on. #CostVR @DavidP4AD @policydeb
1/
$100 in India
$1000 in Europe
$18,000 in USA
No wonder lenalidomide is the #2 drug Medicare spends the most money on. #CostVR @DavidP4AD @policydeb
1/
Why?
17-20 generics in Europe and India bringing down the cost.
2-3 in USA but they are prevented from getting full market share.
2/
17-20 generics in Europe and India bringing down the cost.
2-3 in USA but they are prevented from getting full market share.
2/
I led the first published phase II trial of Lenalidomide. So my interest in the cost is more than cursory. ashpublications.org/blood/article/…
Here are my Top 5 #ASCO22 @ASCO myeloma abstracts. #ASCO22VR
Links to the full abstract. As in the past, I left out studies where similar results were already presented or published before. Top 5 based on new data, clinical impact & methodology
Thread with countdown👇
Links to the full abstract. As in the past, I left out studies where similar results were already presented or published before. Top 5 based on new data, clinical impact & methodology
Thread with countdown👇
#5 Risk adapted maintenance: Len for standard risk & Len plus Bortezomib for high risk gives outstanding results. #ASCO22 #ASCO22VR
Clinically important & updated data are excellent. @RujulParikh @SagarLonialMD @AjayNookaMD @WinshipAtEmory meetings.asco.org/abstracts-pres…
Clinically important & updated data are excellent. @RujulParikh @SagarLonialMD @AjayNookaMD @WinshipAtEmory meetings.asco.org/abstracts-pres…
#4 CAR-T targeting GPRC5D. Doubt if one BCMA approach fails another BCMA approach will give significant benefit. These treatments are incredibly expensive. We need immunotherapy options that target something besides BCMA. @ZJU_China
#ASCO22 #ASCO22VR meetings.asco.org/abstracts-pres…
#ASCO22 #ASCO22VR meetings.asco.org/abstracts-pres…
What do you pay for your meds in the US? I checked commonly used med prices on @GoodRx. Prices vary a lot!
@Lisa_L_Gill did this analysis a few years ago.
I added @costplusdrugs @mcuban to the list. #CostVR
@Lisa_L_Gill did this analysis a few years ago.
I added @costplusdrugs @mcuban to the list. #CostVR
People may not realize that for some meds in the US, the money you pay as insurance copay/coinsurance may be higher than what you can get paying out of pocket without using insurance.
It's one of the mind boggling things about prescription drug prices.
It's one of the mind boggling things about prescription drug prices.
Not even people in healthcare know.
A friend who works in healthcare commented that after I told him about the way meds are priced, he's now saving $1200 a year on just one medicine.
A friend who works in healthcare commented that after I told him about the way meds are priced, he's now saving $1200 a year on just one medicine.
Here are my Top 5 #ASCO21 @ASCO myeloma abstracts. #ASCO21VR
I’ve listed them with links to the full abstract. @mtmdphd @Rfonsi1 @MayoMyeloma @chadinabhan @Mohty_EBMT @BldCancerDoc @szusmani @NBahlis @NoopurRajeMD @profghjackson @contirena1 @DusetzinaS
Thread for countdown👇
I’ve listed them with links to the full abstract. @mtmdphd @Rfonsi1 @MayoMyeloma @chadinabhan @Mohty_EBMT @BldCancerDoc @szusmani @NBahlis @NoopurRajeMD @profghjackson @contirena1 @DusetzinaS
Thread for countdown👇
#5 Daratumumab, bortezomib, lenalidomide, cyclophosphamide and dexamethasone (Dara-CVRd) for ultra high risk MM and plasma cell leukemia. A modern alternative to VDT-PACE. 94% response rate. @profghjackson @MyelomaUK #ASCO21VR #ASCO21
meetinglibrary.asco.org/record/195431/…
meetinglibrary.asco.org/record/195431/…
#4 Financial difficulty in patients with multiple myeloma. 20% of patients reported financial difficulties in 1 year. Glad this is being studied. I do think this is an underestimate. @ALLIANCE_org @theNCI @contirena1 #ASCO21VR #ASCO21
meetinglibrary.asco.org/record/195456/…
meetinglibrary.asco.org/record/195456/…
At a list price of ~$19,000 a month, I will not be using or recommending much of melphalan flufenamide (Pepaxto) for multiple myeloma.
The drug needs to show superiority over cyclophosphamide or melphalan in a randomized trial. #CostVR
The drug needs to show superiority over cyclophosphamide or melphalan in a randomized trial. #CostVR
Myeloma drug costs are unsustainable. They reflect what's going on in all cancers. If key opinion leaders are silent this will continue. Our recommendations must reflect and take into account value.
I said the same when selinexor and panobinostat were approved. Pricing has to be related to incremental value.
Forget the pharma talking point that high prices are needed for innovation. If every drug can be priced high regardless of value there is no incentive for innovation.
Forget the pharma talking point that high prices are needed for innovation. If every drug can be priced high regardless of value there is no incentive for innovation.
My paper on the high cost of prescription drugs and possible solutions is out. I go into how US policies (or lack thereof) affect prices in other countries. #BCJ
#OpenAccess #CostVR #insulin4all @MayoClinic nature.com/articles/s4140…
#OpenAccess #CostVR #insulin4all @MayoClinic nature.com/articles/s4140…
There are no easy answers because the factors contributing to high prices are myriad, and come from all different directions. There are factors unique to the US, which are not operational elsewhere. We need many policy changes in order to have an impact. nature.com/articles/s4140…
Looks like a laundry list of things going on, because a laundry list of things is going on. Everything I mention plays an active role in high prices. We cannot control prices without looking at this 360°
There are things individual docs can do. So don’t wait for policy changes.
There are things individual docs can do. So don’t wait for policy changes.
