Discover and read the best of Twitter Threads about #cov

Most recents (11)

Our latest paper describing #universal #CoV vaccine that can protect against #MERSCoV and #SARSCoV is now out⁩ in #preprint@YaleMed⁩ ⁦

Short thread 👇🏼

“Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice”…
We were interested in developing vaccination strategies against highly pathogenic human #coronaviruses with epidemic potential. Our previous studies, and those of others, defined the #RBD as a major target of neutralizing antibodies.
We therefore looked to #ferritin nanoparticles as a scaffold to display genetically divergent RBDs from both Group 2c merbecoviruses (#MERSCoV) and Group 2b sarbecoviruses (#SARSCoV , #SARSlike viruses, and #SARSCoV2). Our vaccines elicited broad binding antibodies in mice.
Read 6 tweets
1/10 Back home after a full #Coventry week. Read on to see what we found #MovingOurFutures #OurFutureMoves #CovMotoFest - @CovMotoFest @CraigoAshley @TweetSherrie @MattChinnArt - as city of culture 2021, Coventry is thinking about its future with some brilliant people...
2/10 The first thing to say is that #Coventry has some brilliant artists, people able to challenge, design & make new work. In the artist lab we explored the city - it's not all concrete - it has a canal, green areas & 5g (not everywhere)...
3/10 Here are Sunil, Colin & Sabine. What's really impressive is their openness to share ideas & be honest about successes & failures. Sabine taught us about Coventry's history & its history of promoting peace. In the room, artists, academics & civic officers. @Jonestheregen
Read 10 tweets
1/To me, it's nb to differentiate between various subgroups of cyclists. Commuters are different than recreational are different from semi or wannabe pro athletes. (of course some are cross over of any/all segments...) #YYJ #YYJBikes #yyjpoli
2/ @CityOfVictoria is inviting one and all to come for the recreational experience they have created on #VancouverSt - as a destination; not a commuting route.
3/ many orgs are encouraging cyclists to make use of the expanding AAA bike lanes - for recreation and family fun -posting #NeighbourhoodRides experiences, awarding prizes for logging kms..
Read 20 tweets
When were the first human #coronaviruses (CoVs) discovered and studied?

How were these viruses associated with human #disease?

It's time to learn our history about human CoVs, and the scientists and volunteers that allowed us to identify this new group of viruses.

Mid-sixties: HCoV-229E and HCoV-OC43 were identified.
1. Hamre et al. (1966)
2. McIntosh et al. (1967)
3. Tyrrell et al. (1965).

Image: Tyrrell et al. (1965).
Healthy HUMAN volunteers were infected to demonstrate that 229E and OC43 resulted in a common cold.

1. Bradburne et al. (1967, 1972)
2. Hamre et al. (1966)

Image: Bradburne et al. (1967)
Read 7 tweets
A somber Doug Ford beings his rare Saturday update. "Folk the alarm bells are ringing." Says too many people aren't following the rules and more decisive action needs to be taken:
BREAKING: Premier Ford announces social gatherings will be reduced in EVERY region across the province #covid19
So caps of 10 people inside and 25 outside across Ontario for the next 28 days. #covid19
Read 10 tweets
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 68 tweets
Los docentes han montado en tres días un enorme aula digital en unas circunstancias tremendas, sin equipos, con brechas digitales enormes entre compañeros, trabajando 12 horas al día , con instruccciones contrarias cada media hora, con muchos alumnos sin conexión ni equipos,⬇️⬇️
aulas caídas, madres que no saben adjuntar archivos, profesores que atienden a todos sus alumnos y a los compañeros en jornadas interminables porque en su día decidieron pasar de los responsables y autoformarse.Han utilizado classroom, teams meet, zoom, jitsi, edpuzzle, forms⬇️
y por supuesto también Instagram, Facebook, Twitter , telegram y sobre todo Whatsapp. Todo lo que han podido, pedido, sabido, compartido, aprendido y también sufrido y llorado. Hay docentes que apenas han notado el cambio porque ya estaban preparados, y estos docentes cuentan⬇️
Read 7 tweets
1) Stocks to Watch 2020 - February Update THREAD

Overall, +9.75%
8 double digit gainers
3 stocks with 20%+ gains
1 even stock
5 negative returns

2) $ZM - $105.00, up 54.32%, it has been the anti #COV-19 stock but the latest weekly candle ended in the bottom half. I still like long term but it may digest some of the YTD gains which will provide a decent entry area. Above or near the 200d would be great.
3) $SQ - $83.33, up 33.2% YTD, the stock reported solid earnings and looks poised to make a run once the market stops falling and shakes the concerns surrounding the virus. #long shares
Read 16 tweets
Recently published article on origins of #coronavirus suggests:
"The finding of 4 unique inserts in the 2019-nCoV, all of which have identity /similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature."…
however, other reports challenge this interpretation.

"Blast against viral sequence database also showed these insertion sequences widely exist in all kinds of viruses from bacteriophage, influenza, to giant eukaryotic viruses"…
But the authors admit:

"For bat #CoV viruses to gain the gene fragments from HIV-1, it will require both viruses to co-infect the same cells. Because the host cells for bat CoV viruses and HIV-1 are different, the chance for both to exchange genetic materials is negligible."
Read 3 tweets
There is an urgent need to generate effective vaccine against #SARSCoV2. This is such an important topic, and many agencies/labs/companies are working on it. I want to open up this discussion here. Let's unite towards this goal.

Pls RT, chime in with your insights/thoughts.

Learning from previous #CoV studies, what is likely to be the correlate of protection? What vaccine approaches generate best neutralizing antibody (Ab)? How quickly does #CoV generally mutate away from Ab-mediated recognition?

What would be a good preclinical model to test vaccine efficacy against #CoV? How well do antibodies to previous #CoVs cross-react against other members including #SARSCoV1, #MERSCoV and #SARSCoV2?

Read 6 tweets
Concerning the CARONAVIRUS -

Someone got Busy , In The Lab .... If you don t know The virus , How can You Give It A Name , No Cure .... Brilliant timing ! Do you Want The Antidote of This Bug ?

The following information was provided by Timothy Webster
#Coronavirus #US #Patent Number #US7220852B1 Synthesized & Registered/Patented in 2015 [In development since 2003 {This application claims the benefit of U.S. Provisional Patent Application No. 60/465,927 filed Apr. 25, 2003,
which is incorporated herein by reference in its entirety.}]…

The US Coronavirus Patent #expired today 01/21/2020, the sameday the first case was announced in the U.S.
Read 19 tweets

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