Discover and read the best of Twitter Threads about #covax1
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Two arms of the immune system- antibodies (from B cells) and T cells (two types, cytotoxic T cells or CD8+ and helper T cells or CD4+). Th1-CD4 cells and CD8 cells are the main immune defenses against viruses. Antibodies will rise & fall with time (depending on severity #covax1 
Paper looked at SARS-CoV-2-specific CD4+ & CD8+ T cell responses from those who had natural infection with non-variant, compared to variants B.1.1.7, B.1.351, P.1, CAL.20C. Also looked at those vaccinated with Pfizer/Moderna against variants #covax1
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
Several of these variants can affect antibody binding and function (either monoclonal or polyclonal), especially B.1.351 & P.1 (remember prevalence in J&J trial where severe disease outcomes unaffected). T cell responses affect disease severity, #covax1
sciencedirect.com/science/articl…
sciencedirect.com/science/articl…
