Discover and read the best of Twitter Threads about #covbarrier
Most recents (1)
The #COVBARRIER RCT now published @LancetRespirMed & it looks like we have a new COVID tx: Baricitinib
-n=1525 hospitalized COVID pts not on IMV
-lower mortality w/ Bari compared to placebo (10% vs 15%) (NNT = 20) & larger benefit in sicker pts!
-bit.ly/3yDmJ9r
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-n=1525 hospitalized COVID pts not on IMV
-lower mortality w/ Bari compared to placebo (10% vs 15%) (NNT = 20) & larger benefit in sicker pts!
-bit.ly/3yDmJ9r
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COV-BARRIER was a 101 site, double blind RCT performed in 11 countries.
It enrolled hospitalized COVID patients who were hypoxemic (but not on IMV) and had evidence of inflammation.
It had many exclusion criteria including monoclonals, immunesuppression. This is a🔑 point.
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It enrolled hospitalized COVID patients who were hypoxemic (but not on IMV) and had evidence of inflammation.
It had many exclusion criteria including monoclonals, immunesuppression. This is a🔑 point.
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The intervention was 4mg of baricitinib, an orally available JAK1/2 inhibitor, dosed once daily for 14 days or until hospital d/c. (It can be crushed and given by FT).
Bari is an FDA approved treatment for RA. It costs ~$50-75 per pill (thus a 14 day course is ~$700-1000).
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Bari is an FDA approved treatment for RA. It costs ~$50-75 per pill (thus a 14 day course is ~$700-1000).
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