Discover and read the best of Twitter Threads about #covs
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When were the first human #coronaviruses (CoVs) discovered and studied?
How were these viruses associated with human #disease?
It's time to learn our history about human CoVs, and the scientists and volunteers that allowed us to identify this new group of viruses.
A THREAD.
How were these viruses associated with human #disease?
It's time to learn our history about human CoVs, and the scientists and volunteers that allowed us to identify this new group of viruses.
A THREAD.
Mid-sixties: HCoV-229E and HCoV-OC43 were identified.
1. Hamre et al. (1966)
2. McIntosh et al. (1967)
3. Tyrrell et al. (1965).
Image: Tyrrell et al. (1965).
1. Hamre et al. (1966)
2. McIntosh et al. (1967)
3. Tyrrell et al. (1965).
Image: Tyrrell et al. (1965).
Healthy HUMAN volunteers were infected to demonstrate that 229E and OC43 resulted in a common cold.
1. Bradburne et al. (1967, 1972)
2. Hamre et al. (1966)
Image: Bradburne et al. (1967)
1. Bradburne et al. (1967, 1972)
2. Hamre et al. (1966)
Image: Bradburne et al. (1967)
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..."
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily.
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily.
There is an urgent need to generate effective vaccine against #SARSCoV2. This is such an important topic, and many agencies/labs/companies are working on it. I want to open up this discussion here. Let's unite towards this goal.
Pls RT, chime in with your insights/thoughts.
1/n
Pls RT, chime in with your insights/thoughts.
1/n
