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1/ Dear #medtwitter:

Please help. Let’s discuss #EBM.

- a thread. #crazypills
2/ I was commuting to work the other day when I read the results of the EXTEND trial nejm.org/doi/full/10.10…

EXTEND was stopped early after WAKE-UP was published due to “lack of clinical equipoise.”

Interesting. Let’s read WAKE-UP then, I thought.
3/ Here’s the link to WAKE-UP: nejm.org/doi/full/10.10…

Traditionally, systemic tPA has been reserved for patients with ischemic stroke who can be confirmed to have had onset of symptoms within the last 4.5 hours.
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